Glypican4 and CTRP5 in Metabolic Syndrome and the Effect of Exercise on These Adipokines

Not Applicable

Completed

• Conditions: Metabolic Syndrome; Obesity
• Interventions: Behavioral: 3months Exercise

• Registration Number: NCT01688622
• Lead Sponsor: Korea University

Brief Summary

Glypican4, CTRP3, CTRP5 are emerging novel adipokines mediating obesity and inflammation related disorders. RBP4 and adiponectin are well known important adipokines. Therefore, we examine the circulating levels of theses adipokines in the subjects with or without metabolic syndrome. Furthermore, we tried to clarify the effect of exercise on the circulating these adipokines.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-07
• Status Verified: 2012-09
• Primary Completion: 2012-09
• Study Completion: 2012-09
• Study First Submitted: 2012-09-13
• Study First Submitted QC: 2012-09-19
• Study First Posted: 2012-09-20
• Last Update Submitted: 2012-09-20
• Last Update Posted: 2012-09-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• Women between 30 and 60 years of age who had a body mass index (BMI) more than 25 kg/m2
• The subjects of metabolic syndrome and age, gender matched non metabolic syndrome among the participants of Korean SO Study (KSOS) study, which is an ongoing epidemiologic study supported by the Korea Science and Engineering Foundation

Exclusion Criteria

• participants had a history of cardiovascular disease
• any type of diabetes
• stage 2 hypertension
• malignant disease, severe renal, or hepatic disease
• Subjects taking medications that might affect body weight or body composition

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Exercise	3months Exercise	obese women who are volunteers for the 3 months exercise programs

Primary Outcome Measures

Name	Time	Method
The changes of circulating glypican4 levels after 3 months exercise	baseline and 12weeks
The changes of circulating CTRP3 levels after 3 months exercise	baseline and 12weeks
The changes of circulating CTRP5 levels after 3 months exercise	baseline and 12weeks
The changes of circulating RBP4 levels after 3 months exercise	baseline and 12weeks
The changes of circulating adiponectin levels after 3 months exercise	baseline and 12weeks

Secondary Outcome Measures

Name	Time	Method
Circulating glypican4 levels in the subjects with or without metabolic syndrome	baseline
Circulating CTRP3 levels in the subjects with or without metabolic syndrome	baseline
Circulating CTRP5 levels in the subjects with or without metabolic syndrome	baseline
Circulating RBP4 levels in the subjects with or without metabolic syndrome	baseline
Circulating adiponectin levels in the subjects with or without metabolic syndrome	baseline

Trial Locations

Locations (1)

Korea University Guro Hospital; 🇰🇷 Seoul, Korea, Republic of