Willingness to Participate in Clinical Trials Among Black and African Americans

Not Applicable

Completed

• Conditions: Researcher-Subject Relations
• Interventions: Behavioral: Black Respondents Exposure to a Photo

• Registration Number: NCT04938895
• Lead Sponsor: Harvard University

Brief Summary

Despite significant racial disparities in health outcomes, racial minority groups in the United States are not adequately represented in clinical trials, and clinical trial results published in major medical journals often underreport racial demographic data of participants. Lack of diversity in clinical trials threatens the generalizability of study results and reduces the ability of minority groups to benefit from medical advancement and innovation. Prior studies show that Black men are more likely to engage in preventive services when there is racial concordance with their healthcare provider. There is minimal literature about how racial concordance or diversity in clinical trial leadership impacts study enrollment. This project examines whether patients' willingness to participate in randomized clinical trials differs based on the characteristics of the investigator.

Detailed Description

We plan to recruit subjects and randomly assign them to one of four treatments. In each treatment arm, the subject will view a photograph of a real NIH investigator. We experimentally vary treatment along two dimensions: whether the sender is Black or white and whether the sender is male or female.

Our primary aim is to assess whether the subject's stated willingness to participate in a clinical trial led by the investigator. Our secondary aim is to assess whether the subject is a more objective measure of interest in signing up for information on other clinical trials. To assess mechanisms, we will ask the respondent to rate the subject's perceived trustworthiness and quality of the investigator. In addition, we will also assess the subject's perceived attractiveness and age of the investigator as well as the subject's risk aversion, altruism, time preference, and general trust.

Study Timeline

• Study Start: 2021-06-07
• Study First Submitted: 2021-06-22
• Study First Submitted QC: 2021-06-22
• Study First Posted: 2021-06-24
• Primary Completion: 2022-02-21
• Study Completion: 2022-02-21
• Status Verified: 2023-05
• Last Update Submitted: 2023-05-17
• Last Update Posted: 2023-05-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 323

Inclusion Criteria

• participant identifies as Black or White

Exclusion Criteria

• participant doesn't identify as Black or White
• younger than 25 years old, older than 64

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SEQUENTIAL

Arm && Interventions

Group	Intervention	Description
Black Woman Investigator	Black Respondents Exposure to a Photo	Survey respondents are exposed to a Black woman investigator.
White Man Investigator	Black Respondents Exposure to a Photo	Survey respondents are exposed to a white man investigator.
Black Man Investigator	Black Respondents Exposure to a Photo	Survey respondents are exposed to a Black man investigator.
White Woman Investigator	Black Respondents Exposure to a Photo	Survey respondents are exposed to a white woman investigator.

Primary Outcome Measures

Name	Time	Method
Willingness to Participate in a Clinical Trial	February 17, 2022 - February 19, 2022	Survey respondents' willingness to participate in a vaccine clinical trial led by the person in the photo.

Trial Locations

Locations (1)

Harvard University; 🇺🇸 Cambridge, Massachusetts, United States