A multicenter observational study for measurement of SNPs in participants of the Japan Polyp Study Cohort
Not Applicable
- Conditions
- Colorectal cancer
- Registration Number
- JPRN-UMIN000049978
- Lead Sponsor
- ational Cancer Center Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 1230
Inclusion Criteria
Not provided
Exclusion Criteria
non
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Interaction between SNPs of ALDH2 and the effectiveness of aspirin in preventing the development of index lesions (ILs: cancers, adenomas with high-grade dysplasia, and adenomas measuring >= 10 mm) at 4 years
- Secondary Outcome Measures
Name Time Method 1) Interaction between SNPs of ADH1B and the effectiveness of aspirin in preventing the development of ILs at 4 years 2) Interaction between SNPs of CYP2A6 and the effectiveness of aspirin in preventing the development of ILs at 4 years 3) Impacts of SNPs of ALDH2, ADH1B, and CYP2A6 on the development of ILs and adenomas within the JPS Cohort 4) Interaction between SNPs of ALDH2 and the effectiveness of aspirin in preventing the development of adenomas at 4 years 5) Interaction between SNPs of ADH1B and the effectiveness of aspirin in preventing the development of adenomas at 4 years 6) Interaction between SNPs of CYP2A6 and the effectiveness of aspirin in preventing the development of adenomas at 4 years 7) Analyses of 1) to 6) taking into account the age, sex, alcohol intake, smoking, height, and body weight 8) Analyses of 1) to 6) using the site, size, and morphology of colorectal cancer as endpoints