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临床试验/NCT02853513
NCT02853513Unknown不适用

Definition of a Probabilistic Model of the Evolution of an Acute Stress Disorder (ASD ) to a Posttraumatic Stress Disorder (PTSD): an Analytical Prospective Cohort Study of Patients Directly Involved in Attacks Terrorists of 13 November 2015

University Hospital, Tours0 个研究点目标入组 100 人开始时间: 2016年7月最近更新:
适应症

试验速览

阶段
不适用
入组人数
100
主要终点
Post traumatic disorder check list

研究概览

简要总结

The scientific approach of this project proposes to build a cohort of "psychological injuries" post-attack of 13 November 2015. This is called patients "involved", ie patients who directly witnessed the events and having the most either came under automatic gunfire or were close to an explosion, whether or not physically injured.

The main objective is to define and validate a model of transition from acute stress disorder (ASD) to posttraumatic stress disorder (PTSD) for better detection of the risk of unfavorable and thus better patient supported.

The first step is to determine independent risk factors found in analytic prospective cohort study.

Bayesian models are well suited to exercise because they can integrate (i) the context related to the patient, (ii) the context related to the trauma itself, and (iii) the immediate reactions and long-term to the latter . They are particularly suited to understanding the brain disordered by saying down information (prior probability) wrong by improper memory of the traumatic event. The confrontation of these descending information and perceived bottom-information could be partly responsible for the symptoms of PTSD.

Once validated, the model will characterize the individual level the most at risk of unfavorable patients (calculating a probability of developing PTSD) and to assess the epidemiological impact on long-term cohort of event considered.

These determinations are necessary prerequisites to optimize the means of support for these current and future casualties.

The investigators main objective is to define a Bayesian model describing a resilient functioning facing a trauma which also allows to describe a possible evolution of the ASD to PTSD by an error.

The state of PTSD or not will be determined by the PCL-S scale.

详细描述

cohort tracking study

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • patients who directly witnessed the events and having the most either came under automatic gunfire or were close to an explosion, whether or not physically injured

排除标准

  • persons not physically present on the premises at the time of the attacks.
  • Inability to understand or read French.
  • Persons unable to express personal consent under whose major legal or private protection of liberty by judicial or administrative decision , or hospital emergency or without their consent

结局指标

主要结局

Post traumatic disorder check list

时间窗: 6 months after trauma

PTSD diagnose

次要结局

  • Hamilton depression scale(6 months after trauma)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

WISSAM EL HAGE

Professor

University Hospital, Tours

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