Definition of a Probabilistic Model of the Evolution of an Acute Stress Disorder (ASD ) to a Posttraumatic Stress Disorder (PTSD): an Analytical Prospective Cohort Study of Patients Directly Involved in Attacks Terrorists of 13 November 2015
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 主要终点
- Post traumatic disorder check list
研究概览
简要总结
The scientific approach of this project proposes to build a cohort of "psychological injuries" post-attack of 13 November 2015. This is called patients "involved", ie patients who directly witnessed the events and having the most either came under automatic gunfire or were close to an explosion, whether or not physically injured.
The main objective is to define and validate a model of transition from acute stress disorder (ASD) to posttraumatic stress disorder (PTSD) for better detection of the risk of unfavorable and thus better patient supported.
The first step is to determine independent risk factors found in analytic prospective cohort study.
Bayesian models are well suited to exercise because they can integrate (i) the context related to the patient, (ii) the context related to the trauma itself, and (iii) the immediate reactions and long-term to the latter . They are particularly suited to understanding the brain disordered by saying down information (prior probability) wrong by improper memory of the traumatic event. The confrontation of these descending information and perceived bottom-information could be partly responsible for the symptoms of PTSD.
Once validated, the model will characterize the individual level the most at risk of unfavorable patients (calculating a probability of developing PTSD) and to assess the epidemiological impact on long-term cohort of event considered.
These determinations are necessary prerequisites to optimize the means of support for these current and future casualties.
The investigators main objective is to define a Bayesian model describing a resilient functioning facing a trauma which also allows to describe a possible evolution of the ASD to PTSD by an error.
The state of PTSD or not will be determined by the PCL-S scale.
详细描述
cohort tracking study
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •patients who directly witnessed the events and having the most either came under automatic gunfire or were close to an explosion, whether or not physically injured
排除标准
- •persons not physically present on the premises at the time of the attacks.
- •Inability to understand or read French.
- •Persons unable to express personal consent under whose major legal or private protection of liberty by judicial or administrative decision , or hospital emergency or without their consent
结局指标
主要结局
Post traumatic disorder check list
时间窗: 6 months after trauma
PTSD diagnose
次要结局
- Hamilton depression scale(6 months after trauma)
研究者
WISSAM EL HAGE
Professor
University Hospital, Tours
