Carotid Body Removal for the Treatment of Chronic Diseases Characterized by Excessive Central Sympathetic Activity Including Resistant Hypertension: a Pilot Study.

Noblewell1 site in 1 country4 target enrollmentJanuary 2013

ConditionsHypertension

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Hypertension
Sponsor: Noblewell
Enrollment: 4
Locations: 1
Primary Endpoint: Change of Blood Pressure
Status: Completed
Last Updated: 9 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

This is a pilot study to assess the effectiveness, safety and feasibility of carotid body removal in patients with high blood pressure (hypertension) resistant to medical treatment. Patients with high blood pressure are at significant risk of medical complications including stroke and heart disease. The principle research question is whether removal of the carotid body will lead to an improvement in the blood pressure of this patient group.

Registry

clinicaltrials.gov

Start Date

January 2013

End Date

June 2016

Last Updated

9 years ago

Study Type

Interventional

Study Design

Single Group

Sex

All

Investigators

Sponsor

Noblewell

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Age of participants will be 18-75 years
•Resistant HTN criteria:
•Daytime mean ambulatory systolic blood pressure ≥135mmHg and office systolic blood pressure ≥150mmHg
•Patients on at least three anti-hypertensive medications, including a diuretic, at maximum tolerated dose
•No evidence of causes for secondary HTN following thorough clinical assessment
•Patient medication concordance will be monitored via medication/blood pressure diary