Airway Pressure During Nasal High Flow and CPAP in Neonates
- Conditions
- Respiratory Insufficiency
- Interventions
- Device: NHF small cannulaDevice: CPAPDevice: NHF big cannula
- Registration Number
- NCT02632799
- Lead Sponsor
- Research Center of Maternal and Child Health Protection, Armenia
- Brief Summary
Nasal High Flow (NHF) and CPAP are established forms of respiratory support in neonates and often produce similar clinical outcomes. The aim of the study was to investigate airway pressure during NHF and CPAP in neonates.
- Detailed Description
Methods: A physiological study which measured pressure intra-nasally with micro (750 µm) pressure probes (Millar, USA) in 10 (5M / 5F) healthy newborns with mean gestation age 37.18 (SD 1.29) wk and mean birth weight of 2414 (SD 503.13) g. NHF was applied at 8 L/min (AIRVO 2) through smaller (OPT 314) and larger (OPT 316) Optiflow nasal cannula; CPAP 5 cmH20 was produced by a Bubble CPAP system and nasal mask interface at constant flow 8 L/min (Fisher \& Paykel Healthcare, NZ). Values are expressed in cmH20 as means and standard deviations (SD).
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 10
- Healthy term newborns
- Newborns with any medical problems after birth
- Absent of parents consents
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description NHF small cannula NHF small cannula NHF 8 L/min (Airvo2) , Smaller cannula (neonatal, yellow) Mask CPAP CPAP CPAP 5cm H2O NHF big cannula NHF big cannula NHF 8 L/min (Airvo2) , Bigger cannula (neonatal, purple)
- Primary Outcome Measures
Name Time Method Upper airway pressure generated by NHF compared to CPAP Up to 1 hour Pressure in upper airways
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (2)
Neonatal Intensive Care Unit, Research Centre of Maternal and Child Health
🇦🇲Yerevan, Armenia
RCMCHP
🇦🇲Yerevan, Armenia