Airway Pressure During Nasal High Flow and CPAP in Neonates
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Respiratory Insufficiency
- Sponsor
- Research Center of Maternal and Child Health Protection, Armenia
- Enrollment
- 10
- Locations
- 2
- Primary Endpoint
- Upper airway pressure generated by NHF compared to CPAP
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
Nasal High Flow (NHF) and CPAP are established forms of respiratory support in neonates and often produce similar clinical outcomes. The aim of the study was to investigate airway pressure during NHF and CPAP in neonates.
Detailed Description
Methods: A physiological study which measured pressure intra-nasally with micro (750 µm) pressure probes (Millar, USA) in 10 (5M / 5F) healthy newborns with mean gestation age 37.18 (SD 1.29) wk and mean birth weight of 2414 (SD 503.13) g. NHF was applied at 8 L/min (AIRVO 2) through smaller (OPT 314) and larger (OPT 316) Optiflow nasal cannula; CPAP 5 cmH20 was produced by a Bubble CPAP system and nasal mask interface at constant flow 8 L/min (Fisher \& Paykel Healthcare, NZ). Values are expressed in cmH20 as means and standard deviations (SD).
Investigators
Eligibility Criteria
Inclusion Criteria
- •Healthy term newborns
Exclusion Criteria
- •Newborns with any medical problems after birth
- •Absent of parents consents
Outcomes
Primary Outcomes
Upper airway pressure generated by NHF compared to CPAP
Time Frame: Up to 1 hour
Pressure in upper airways