跳至主要内容
临床试验/CTRI/2024/01/062060
CTRI/2024/01/062060尚未招募4 期

A Randomized clinical study to evaluate the efficacy of sirvyadha with or without jatamayadi lepa in vata - rakta w.s.r to gout

Dr Sambu Surendran1 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2024年2月10日最近更新:
适应症

试验速览

阶段
4 期
状态
尚未招募
发起方
入组人数
40
试验地点
1
主要终点
1)reduction in the range of serum uric acid will be assessed.

研究概览

简要总结

Vatarakta is a metabolic disorder and a grievous medical condition. It is one among Vatavyadi caused due to avarana (occlusion). As the name suggest it is due to the vitiation of Vata Dosha and Rakta Dhatu (blood). Vatarakta is classified in to - Uttana Vatarakta and Gambhira Vatarakta on the basis of dhatu involvement, symptoms of uthana vatarakta are Kandu, Daha, Ruja, Ayama, Toda, Spurana, Kunchana, Raga, Bheda, Gourava and Suptata.

Gout is a common type of arthritis; the symptomatology of this has striking similarities with those explained in Vatarakta

This is due to excess accumulation of uric acid  in the blood stream which  forms crystals in the joint that causes intense pain,  swelling  and  stiffness in phalanges,  it  usually  affects  the  joint  of  the  big  toe and is marked  by  transient painful attacks of acute arthritis initiated by crystallization of urates,eventually it leads to chronic gouty arthritis and the deposition of masses of Monosodium  Urate  (MSU)  crystals    in  joints  and  other sites,  creating  tophi. The essential biochemical requirement for the development of clinical gout is hyperuricemia.                 The management of Vatarakta aims at Vata Hara and Rakta Prasadaka measures.  In this respect the Shodhana chikitsa like Raktamokshana (Siravyadha)  is advised as primary treatment by Acharya, Raktamokshana  (Siravyadha)  is  a  unique  subset  of accredited drugless surgical technique in Ayurveda; often ignored,  misunderstood  in  the  mainstream  practice. It is indicated primarily in generalized vitiation of blood, causing distress.  Siravyadha treatment relieves the symptoms early, modifies the underlying pathology and also reduces the duration of treatment. it can  bring  down  the  oral  medicine  burden  to  the  patient which has to be taken for years together.

In sahasrayoga, thaila prakarana, kalka dravya of balaguluchyadi taila i.e., Jadamayadhi churna which ingredients are sheeta veerya   can reduces raga, shopha, daha and shola caused due to vata rakta.

研究设计

研究类型
Interventional
分配方式
Randomized
盲法
None

入排标准

年龄范围
20.00 Year(s) 至 65.00 Year(s)(—)
性别
All

入选标准

  • •a.Subject with hyperuricemia and presenting with lakshanas of Vatarakta.
  • •b.Chronicity less than 5 years, c.Not associated with complete joint destruction.
  • •d.Uric acid above 7 mg/dl.

排除标准

  • •Subject with major illness like hepatitis, AIDS, malignancy and RA factor positive.
  • •Subject with uncontrolled diabetes mellitus and hypertension, Koch’s arthritis, Septic arthritis, Chronic renal failure, Severe Systemic multi organ syndromes and uric acid cristal stones.
  • •Subjects on opioids, anticoagulant drugs.
  • •Classical contraindications for siravyadha procedure.

结局指标

主要结局

1)reduction in the range of serum uric acid will be assessed.

时间窗: Base line - serum uric acid will be assessed and 1 st sitting of Siravyadha | 1 st follow up after 7days and second sitting of siravyadha serum uric acid will be assessed | 2 nd follow up 21 days after baseline and 3 rd sitting of siravyadha , serum uric acid will be assessed | 3rd followup after 28 days of baseline and 4th sitting of siravyadha , serum uric acid will be assessed

次要结局

  • 1)reduction in the range of serum uric acid(2) symptomatic changes like pain , burining sensation , swelling & discoloration after inntervention)

研究者

发起方
Dr Sambu Surendran
申办方类型
Private medical college
责任方
Principal Investigator
主要研究者

Dr Sambu Surendran

HASS Ayurveda Mahavidhyalaya Hubballi.

研究点 (1)

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