Effect of Gastric Bypass Surgery on Brain Responses

Not Applicable

Suspended

• Conditions: Obesity; Hormone Responses; Cognitive Health

• Registration Number: NCT01815216
• Lead Sponsor: Uppsala University

Brief Summary

After obesity surgery gastric bypass (GBP) patients usually lose more than 50% of its former preponderance in relative short time (\~ 2 years). But knowledge of the underlying biological mechanisms of decline in body weight is still inadequate.

This project intends to examine patients' background activity in the brain (i.e. "the resting state activity") and brain volume using MRI both before and one year after surgery.

Detailed Description

We will also investigate whether hormonal changes in response to food intake after obesity surgery is associated with patients' impulsive control when exposed to pictures of food in the MRI.

Study Timeline

• Study Start: 2013-03
• Study First Submitted: 2013-03-18
• Study First Submitted QC: 2013-03-18
• Study First Posted: 2013-03-20
• Status Verified: 2015-06
• Last Update Submitted: 2015-06-01
• Last Update Posted: 2015-06-02
• Primary Completion: 2016-12
• Study Completion: 2016-12

Recruitment & Eligibility

• Status: SUSPENDED
• Sex: Female
• Target Recruitment: 48

Inclusion Criteria

• female
• right-handed
• scheduled for bariatric surgery in the Academic Hospital of Uppsala, Sweden

Exclusion Criteria

• undergone more than one bariatric surgery
• suffer from mental disorders (depression, phobias, etc.) that can not be controlled with treatment.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Change in background activity in the brain (resting state activity) after bariatric surgery	1 year	Brain's basic activity and structure will be measured on 3 occasions: 4 weeks before bariatric surgery, 4 weeks after surgery and 1 year after surgery, using fMRI.

Secondary Outcome Measures

Name	Time	Method
Change in response inhibition after bariatric surgery	1 year	Inhibitory control to food cues will be measured on 3 occasions: 4 weeks before bariatric surgery, 4 weeks after surgery and 1 year after surgery, using a NoGo-Go task.

Trial Locations

Locations (1)

Academic Hospital; 🇸🇪 Uppsala, Sweden