Mechanisms of Nocturnal Hypertension and Non-Dipping Blood Pressure Patterns
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 59
- 试验地点
- 1
- 主要终点
- 24-hour blood pressure
研究概览
简要总结
The purpose of this study is to determine if high salt diet contributes to high nighttime blood pressure. The investigators will determine if high compared to low salt diet increases 24-hour blood pressure levels. The investigators will also determine if high salt diet affects blood vessel stiffness, cardiac output, and sleep apnea. The study will also determine how high salt diet affects the activity of certain genes related to control of blood pressure. A total of 60 participants will be enrolled in the study.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
盲法说明
Both the participant and investigator are blinded to the diet
入排标准
- 年龄范围
- 48 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Nocturnal hypertension
排除标准
- •Stage 2 clinic hypertension
- •History of congestive heart failure
- •Chronic kidney disease,
- •Diabetes with insulin use
- •History of a cardiovascular event
- •Pregnant or nursing
- •Current use of continuous positive airway pressure
- •Shift work
- •A known circadian rhythm disorder
研究组 & 干预措施
High sodium diet
High sodium diet is 6 g sodium per day for 10 days
干预措施: Dietary sodium (Dietary Supplement)
Low sodium diet
Low sodium diet is 1.5 g sodium per day for 10 days
干预措施: Dietary sodium (Dietary Supplement)
结局指标
主要结局
24-hour blood pressure
时间窗: Baseline to 7 days after start of dietary period
Blood pressure measured by an ambulatory blood pressure monitor
次要结局
- Obstructive sleep apnea(Baseline to 7 days after start of dietary period)
研究者
David Calhoun
Professor
University of Alabama at Birmingham