Impact of radiotherapy and radiotherapy technique on neurocognitive profile in grade 2 and 3 gliomas.
- Conditions
- Health Condition 1: C719- Malignant neoplasm of brain, unspecified
- Registration Number
- CTRI/2024/06/069040
- Lead Sponsor
- Post Graduate Institute of Medical Education and Research PGIMER Chandigarh
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
1.Patients with infiltrative lower grade gliomas (grade 2-3) who have undergone tumor removal or at least biopsy with histopathologic confirmation.
2.Cranial radiotherapy is clinically indicated to prevent recurrence due to presence of high risk features (astrocytoma histology), subtotal resection (STR) or age older than 40 years.
3.Karnofsky Performance Status Scale score (KPS)
more than or equal to 60.
4.No prior history of radiation to the brain.
5.No contraindications to contrast enhanced computed tomography (CECT) and contrast enhanced magnetic resonance imaging (CEMRI).
6.Routine blood parameters (Complete blood count (CBC), liver function test (LFT), kidney function test (KFT)) within normal limits.
7.Willing to give consent for the study.
1)Any non malignant known CNS disease that can cause neurocognitive dysfunction.
2)Pregnant and lactating women.
3)Prior long term chemotherapy.
4)Moderate or severe neurocognitive dysfunction prior to radiotherapy (MMSE less than or equal to 18)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method