High intensity interval training in patients with a right ventricle to pulmonary artery conduit

Conditions: Congenital Heart Disease
Congenital absence of an unobstructed connection between the right ventricle and pulmonary artery (Truncus arteriosus
Other forms of pulmonary atresia with biventricular correction)
Pulmonary atresia with ventricular septum defect
Severe tetralogy of Fallot
10010394
10007510
10007593

Registration Number: NL-OMON56579

Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 49

Inclusion Criteria

1. Congenital absence of an unobstructed connection between the right ventricle
and pulmonary artery, requiring surgical implantation of an RV-PA conduit,
including patients with:
a. Truncus arteriosus
b. Pulmonary atresia with ventricular septum defect
c. Severe tetralogy of Fallot
d. Other forms of pulmonary atresia with biventricular correction
2. Age 12 to 35 years.
3. Current follow-up in ACAHA.
4. Signed informed consent.

Exclusion Criteria

1. Ventricular arrhythmias and/or channelopathy.
2. ICD implanted due to inherited arrhythmia syndromes
3. Left ventricular ejection fraction (LV EF) and/or right ventricular ejection
fraction
(RV EF) <30%
4. Elite athletes (i.e. national team, Olympians, professional athletes,
exercising >=10 h/week, according to definition in 2020 ESC Guidelines for
Sports Cardiology and Exercise in Patients with Cardiovascular Disease).(37)
5. Cardiovascular lesions requiring intervention (according to international
guidelines)
6. Cardiovascular intervention (surgery or catheterization) less than 12 months
ago.
7. Cardiovascular medication changes less than 3 months ago.
8. Hospitalization for treatment of cardiovascular events less than 6 months
ago.
9. Comorbidities or developmental delay impeding exercise training (e.g.
neuromuscular disease, symptomatic myocardial ischemia, syndromic diagnoses
such as trisomy 21).
10. Inability to provide informed consent.