Administration of 5% Dextrose/Hartmann's solution compared with 5% Dextrose/Half Normal (0.45%) Saline following spinal instrumentation surgery or craniotomy in children results in less post-operative hyponatraemia.

Phase 3

Completed

• Conditions: Post-operative hyponatraemia; Blood - Other blood disorders

• Registration Number: ACTRN12607000116426
• Lead Sponsor: Dr Mark Coulthard

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2007-02-08
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

* Patients who are admitted to the Paediatric Intensive Care Unit (PICU) (elective or emergency) following spinal fusion or craniotomy surgery. * Spinal fusion surgery includes posterior spinal instrumentation and fusion.* Craniotomy surgery includes excision of tumours and surgical correction of craniostenoses.

Exclusion Criteria

* Parents/Guardians who are unable to read and write English.* Patients undergoing lengthening only of spinal growth rods, revision/insertion of ventriculoperitoneal (VP) shunts.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Hyponatraemia is defined as a plasma sodium concentration of less than 135mmol/L and will be measured by arterial blood gas analysis via Radiometer Copenhagen, ABL 725[Sodium levels will be measured within 1 hour and 12-16 hours post-operatively.]

Secondary Outcome Measures

Name	Time	Method
Change in serum Antidiuretic Hormone (ADH) levels.[Serum ADH levels will be measured at induction of surgery and 16 hrs post-operative. ];Amount of fluid bolus requirements in mls/kg up to 16 hrs post-operative.[12-16h post surgery]