Rhythmic Auditory Stimulation on Neural Activity During Finger-tapping in PD Patients
- Conditions
- Parkinson DiseaseElectroencephalographyAcoustic Stimulation
- Interventions
- Behavioral: noF-noRASBehavioral: F-noRASBehavioral: noF-100RASBehavioral: F-100RASBehavioral: F-105RASBehavioral: F-110RAS
- Registration Number
- NCT05839821
- Lead Sponsor
- The Hong Kong Polytechnic University
- Brief Summary
Introduction Bradykinesia (i.e., slow movements) is one of the most prominent symptoms of Parkinson's disease (PD) and has a negative impact on quality of life. Rhythmic auditory stimulation (RAS), a widely used and promising treatment technique, has been shown to effectively improve gait speed in PD patients. However, only few studies have explored effects and neural mechanisms of RAS on upper-limb movements. The investigators will conduct two studies to investigate effects and mechanisms of RAS on upper-limb movements in PD patients. The purpose of this study is to examine real-time neural activity when patients with PD and healthy controls listen to RAS and execute finger-tapping task simultaneously.
Methods and analysis This study will recruit patients with PD and healthy controls. Electroencephalography (EEG) will be used under six conditions related to a finger-tapping task. Two-way repeated measures analysis of variance will be performed to investigate the group and condition effects on neural mechanisms.
Study significance This study will offer evidence on RAS effects and mechanisms by investigating the changes in upper-limb movements and neural mechanisms during auditory-motor entrainment. Results from this study will provide a solid foundation for further research and clinical applications of RAS.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 72
- (a) idiopathic PD diagnosed by a neurologist based on the Movement Disorders Society clinical diagnostic criteria;
- (b) the Hoehn and Yahr stage is 2 or 3, meaning that bilateral movement problems or combination with mild postural instability;
- (c) a score of Montreal Cognitive Assessment (MoCA) is equal to or higher than 21 to ensure that they understand experimental instructions;
- (d) a score of Edinburgh Handedness Inventory is above 60 to ensure that they are right-handed;
- (e) types and doses of medications remain unchanged in the past month right before participation.
- Age- and sex-matched healthy controls who filled the criteria (c) and (d) will be recruited from communities.
- the presence of medical conditions or diseases that may affect hand movements, vision, or hearing based on self-report.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description PD patients F-noRAS Patients with Parkinson's disease PD patients F-100RAS Patients with Parkinson's disease Healthy controls noF-noRAS Healthy older adults Healthy controls noF-100RAS Healthy older adults Healthy controls F-110RAS Healthy older adults Healthy controls F-105RAS Healthy older adults PD patients noF-noRAS Patients with Parkinson's disease PD patients noF-100RAS Patients with Parkinson's disease PD patients F-105RAS Patients with Parkinson's disease PD patients F-110RAS Patients with Parkinson's disease Healthy controls F-100RAS Healthy older adults Healthy controls F-noRAS Healthy older adults
- Primary Outcome Measures
Name Time Method The spectral power analysis of Electroencephalography (EEG) EEG will be continuously recorded during the whole experiment, which is about 20 minutes. The spectral power analysis (unit: watt) will be conducted
The functional connectivity analysis of Electroencephalography (EEG) EEG will be continuously recorded during the whole experiment, which is about 20 minutes. The functional connectivity analysis (unit: coherence) will be conducted
- Secondary Outcome Measures
Name Time Method