The Use of Point-of-Care Ultrasound in the Diagnosis of Acute Infectious Mononucleosis in the Emergency Department
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 200
- 试验地点
- 2
- 主要终点
- Presence of splenomegaly (maximal splenic cranio-caudal length) on point-of-care ultrasound
研究概览
简要总结
The purpose of this study is to determine if splenomegaly on point-of-care ultrasound (POCUS) is an accurate and user-friendly surrogate to the heterophile antibody test and Epstein-Barr Virus (EBV) serologies to diagnose acute mononucleosis infection in patients presenting with sore throat to the Emergency Department (ED).
详细描述
The investigators seek to determine whether the presence of splenomegaly on POCUS can accurately diagnose acute infectious mononucleosis in symptomatic ED patients, and determine the feasibility of performing point-of-care ultrasound for splenomegaly by emergency physicians in the emergency department setting.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 10 Years 至 35 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients aged between 10 and 35 year-old presenting to the ED with suspected acute infectious mononucleosis
排除标准
- •Chronic infectious disorders (eg. tuberculosis, malaria, HIV, syphilis)
- •Inflammatory disorders (eg. sarcoidosis, amyloidosis, systemic lupus erythematosus, Felty syndrome)
- •Proliferative disorders (eg. lymphoma, leukemia, essential thrombocytopenia, polycythemia vera)
- •Congestive disorders (eg: cirrhosis, portal hypertension, right heart failure, congenital heart disease)
- •Chronic haemolytic anemia (eg. sickle cell, thalassemia, hereditary spherocytosis)
- •Storage diseases (eg. Gaucher, Niemann-Pick)
- •Splenectomy
- •Inability to give informed consent
结局指标
主要结局
Presence of splenomegaly (maximal splenic cranio-caudal length) on point-of-care ultrasound
时间窗: 12 months
Splenomegaly is defined as a splenic length of \> 11.5 centimetres (cm) for 10-12 year-old patients, \> 12 cm for 12-15 year-old patients, \> 12 cm for 15-35 year-old female patients, and \> 13 cm for 15-35 year-old male patients.
次要结局
未报告次要终点
研究者
Laurie Robichaud
Laurie Robichaud, MD
Jewish General Hospital