The Use of Point-of-Care Ultrasound in the Diagnosis of Acute Infectious Mononucleosis in the Emergency Department
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Infectious Mononucleosis
- Sponsor
- Jewish General Hospital
- Enrollment
- 200
- Locations
- 2
- Primary Endpoint
- Presence of splenomegaly (maximal splenic cranio-caudal length) on point-of-care ultrasound
- Status
- Terminated
- Last Updated
- 5 years ago
Overview
Brief Summary
The purpose of this study is to determine if splenomegaly on point-of-care ultrasound (POCUS) is an accurate and user-friendly surrogate to the heterophile antibody test and Epstein-Barr Virus (EBV) serologies to diagnose acute mononucleosis infection in patients presenting with sore throat to the Emergency Department (ED).
Detailed Description
The investigators seek to determine whether the presence of splenomegaly on POCUS can accurately diagnose acute infectious mononucleosis in symptomatic ED patients, and determine the feasibility of performing point-of-care ultrasound for splenomegaly by emergency physicians in the emergency department setting.
Investigators
Laurie Robichaud
Laurie Robichaud, MD
Jewish General Hospital
Eligibility Criteria
Inclusion Criteria
- •Patients aged between 10 and 35 year-old presenting to the ED with suspected acute infectious mononucleosis
Exclusion Criteria
- •Chronic infectious disorders (eg. tuberculosis, malaria, HIV, syphilis)
- •Inflammatory disorders (eg. sarcoidosis, amyloidosis, systemic lupus erythematosus, Felty syndrome)
- •Proliferative disorders (eg. lymphoma, leukemia, essential thrombocytopenia, polycythemia vera)
- •Congestive disorders (eg: cirrhosis, portal hypertension, right heart failure, congenital heart disease)
- •Chronic haemolytic anemia (eg. sickle cell, thalassemia, hereditary spherocytosis)
- •Storage diseases (eg. Gaucher, Niemann-Pick)
- •Splenectomy
- •Inability to give informed consent
Outcomes
Primary Outcomes
Presence of splenomegaly (maximal splenic cranio-caudal length) on point-of-care ultrasound
Time Frame: 12 months
Splenomegaly is defined as a splenic length of \> 11.5 centimetres (cm) for 10-12 year-old patients, \> 12 cm for 12-15 year-old patients, \> 12 cm for 15-35 year-old female patients, and \> 13 cm for 15-35 year-old male patients.