The Use of Point-of-Care Ultrasound in the Diagnosis of Acute Infectious Mononucleosis in the Emergency Department

Terminated

• Conditions: Splenomegaly; Infectious Mononucleosis

• Registration Number: NCT02463669
• Lead Sponsor: Jewish General Hospital

Brief Summary

The purpose of this study is to determine if splenomegaly on point-of-care ultrasound (POCUS) is an accurate and user-friendly surrogate to the heterophile antibody test and Epstein-Barr Virus (EBV) serologies to diagnose acute mononucleosis infection in patients presenting with sore throat to the Emergency Department (ED).

Detailed Description

The investigators seek to determine whether the presence of splenomegaly on POCUS can accurately diagnose acute infectious mononucleosis in symptomatic ED patients, and determine the feasibility of performing point-of-care ultrasound for splenomegaly by emergency physicians in the emergency department setting.

Study Timeline

• Study First Submitted: 2015-05-31
• Study First Submitted QC: 2015-06-03
• Study First Posted: 2015-06-04
• Study Start: 2016-04
• Status Verified: 2020-10
• Primary Completion: 2020-10-04
• Study Completion: 2020-10-04
• Last Update Submitted: 2020-10-04
• Last Update Posted: 2020-10-06

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• Patients aged between 10 and 35 year-old presenting to the ED with suspected acute infectious mononucleosis

Exclusion Criteria

• Chronic infectious disorders (eg. tuberculosis, malaria, HIV, syphilis)
• Inflammatory disorders (eg. sarcoidosis, amyloidosis, systemic lupus erythematosus, Felty syndrome)
• Proliferative disorders (eg. lymphoma, leukemia, essential thrombocytopenia, polycythemia vera)
• Congestive disorders (eg: cirrhosis, portal hypertension, right heart failure, congenital heart disease)
• Chronic haemolytic anemia (eg. sickle cell, thalassemia, hereditary spherocytosis)
• Storage diseases (eg. Gaucher, Niemann-Pick)
• Splenectomy
• Inability to give informed consent

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Presence of splenomegaly (maximal splenic cranio-caudal length) on point-of-care ultrasound	12 months	Splenomegaly is defined as a splenic length of \> 11.5 centimetres (cm) for 10-12 year-old patients, \> 12 cm for 12-15 year-old patients, \> 12 cm for 15-35 year-old female patients, and \> 13 cm for 15-35 year-old male patients.

Trial Locations

Locations (2)

Jewish General Hospital; 🇨🇦 Montreal, Quebec, Canada

CHU Sainte-Justine; 🇨🇦 Montreal, Quebec, Canada