Intermittent Fasting Versus Dietary Approach to Stop Hypertension on Metabolic Risk Profile in Nonalcoholic Fatty Liver Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Fasting, Intermittent
- Sponsor
- Cairo University
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- assessment of Non-alcoholic fatty liver using ultrasonography
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
This study was conducted to compare between the effect of intermittent fasting and diatery approach to stop hypertension on metabolic risk profile in nonalcoholic fatty liver patients.
Detailed Description
Non-alcoholic fatty liver is a liver disease linked to obesity, insulin resistance, type 2 diabetes, hypertension, hyperlipidemia, and metabolic syndrome. The subtype, non-alcoholic steatohepatitis, can lead to liver fibrosis, cirrhosis, hepatocellular carcinoma, and liver transplantation. The prevalence of Non-alcoholic fatty liver disease is increasing at the same rate as obesity, with the global prevalence estimated at 25%. By 2020, the burden of Non-alcoholic fatty liver is expected to exceed that of communicable disease in most regions.
Investigators
Aya Gamal Khattab Omer
principal investigator
Cairo University
Eligibility Criteria
Inclusion Criteria
- •Non-alcoholic fatty liver patients diagnosed by radiological ultrasound
- •All patients are sedentary lifestyle with little or no exercise.
- •High lipid profile (total cholesterol \> 200, LDL \> 130, TAGs \> 150) patients by laboratory investigation.
- •High fasting insulin level \> 20mlU/mL \& high fasting Glucose level \>100, HbA1c \> 5.7 \& high HOMA- IR \> 2.5 patients by Laboratory investigation.
- •High inflammatory markers (IL6) patients.
- •Age ranged from 30 to 40 years old.
Exclusion Criteria
- •Alcoholic fatty liver patients.
- •Cirrhosis patients.
- •Diabetes patients.
- •Cognitive impaired patients.
- •History of epilepsy patients.
- •Cardiac pacemaker patients.
- •Anemic patients
- •pregnancy
Outcomes
Primary Outcomes
assessment of Non-alcoholic fatty liver using ultrasonography
Time Frame: at baseline at after two months
usage of diagnostic ultrasound to diagnose patients with non-alcoholic fatty liver disease
Secondary Outcomes
- assessment of change of lab profile using laboratory investigations(at baseline at after two months)
- assessment of change of body mass index(at baseline at after two months)
- assessment of macronutrients distribution(at baseline at after two months)