Oxidative Stress Markers in COPD

Completed

• Conditions: Role of Oxidative Stress in COPD
• Interventions: Other: oxidative stess markers

• Registration Number: NCT04748887
• Lead Sponsor: Minia University

Brief Summary

Background:Striking feature of Chronic obstructive pulmonary disease (COPD) is its inability to resolve after cigarette smoke exposure has ended, which has contributed to the possibility that the disease could also be driven by other endogenous causes, such as autoimmunity or chronic infection . Many of the pathogenetic pathways involved in COPD and its development tend to be driven by oxidative stress.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-09-01
• Primary Completion: 2019-04-01
• Study Completion: 2019-09-01
• Status Verified: 2021-02
• Study First Submitted: 2021-02-05
• Study First Submitted QC: 2021-02-09
• Last Update Submitted: 2021-02-09
• Study First Posted: 2021-02-10
• Last Update Posted: 2021-02-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

• 1-Forty subjects of COPD who are non-smokers or stopped smoking for more than 6 months Based on the Global Initiative for Chronic Obstructive Lung Disease guidelines, COPD was diagnosed.9 2- Thirty subjects of non smokers healthy control

Exclusion Criteria

• Patients of:

  1. Acute exacerbation, at the time of the study, of COPD.
  2. Any obvious abnormal lung parenchymal lesions.
  3. Lung cancer.
  4. Congestive heart failure.
  5. current smokers
  6. Drugs e.g anti-inflammatory , steroids ,analgesics, insulin , antineoplastic, antipsychotic drugs in the previous 2 weeks before the study.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
nonsmokers copd cases ,	oxidative stess markers	Fourty subjects of COPD who are non-smokers or stopped smoking for more than 6 months
non smokers healthy control	oxidative stess markers	Thirty subjects of non smokers healthy control

Primary Outcome Measures

Name	Time	Method
oxidative stress markers in non smokers COPD compared to healthy control	1month	markers of oxidative stress , Superoxide Dismutase (SOD) and Malondialdehyde (MDA) by ( ELISA Kit SinoGeneClon Biotech Co.,Ltd Catalog No : SG- 10188) .

Trial Locations

Locations (1)

Minia University Hospital; 🇪🇬 Multiple Locations, Minia, Egypt