Chronic Obstructive Pulmonary Disease in Non Smokers:Role of Oxidative Stress
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Role of Oxidative Stress in COPD
- Sponsor
- Minia University
- Enrollment
- 70
- Locations
- 1
- Primary Endpoint
- oxidative stress markers in non smokers COPD compared to healthy control
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
Background:Striking feature of Chronic obstructive pulmonary disease (COPD) is its inability to resolve after cigarette smoke exposure has ended, which has contributed to the possibility that the disease could also be driven by other endogenous causes, such as autoimmunity or chronic infection . Many of the pathogenetic pathways involved in COPD and its development tend to be driven by oxidative stress.
Investigators
zainab hassan saeed
principle investigator ,faculty of medicine,department of chest diseases,Minia University
Minia University
Eligibility Criteria
Inclusion Criteria
- •1-Forty subjects of COPD who are non-smokers or stopped smoking for more than 6 months Based on the Global Initiative for Chronic Obstructive Lung Disease guidelines, COPD was diagnosed.9 2- Thirty subjects of non smokers healthy control
Exclusion Criteria
- •Patients of:
- •Acute exacerbation, at the time of the study, of COPD.
- •Any obvious abnormal lung parenchymal lesions.
- •Lung cancer.
- •Congestive heart failure.
- •current smokers
- •Drugs e.g anti-inflammatory , steroids ,analgesics, insulin , antineoplastic, antipsychotic drugs in the previous 2 weeks before the study.
Outcomes
Primary Outcomes
oxidative stress markers in non smokers COPD compared to healthy control
Time Frame: 1month
markers of oxidative stress , Superoxide Dismutase (SOD) and Malondialdehyde (MDA) by ( ELISA Kit SinoGeneClon Biotech Co.,Ltd Catalog No : SG- 10188) .