A clinical trial to compare the effect of a drug dexmedetomidine when given intramuscularly and in nerve block in patients receiving anaesthesia for forearm and hand surgeries

Not yet recruiting

Conditions: Other specified acquired deformities of musculoskeletal system,

Registration Number: CTRI/2021/04/033190

Lead Sponsor: Sanjana S

Brief Summary: Supraclavicular brachial plexus blocks are commonly administered in upper limb surgeries. Adjuvants such as dexmedetomidine, clonidine, dexamethasone etc are added in the block to prolong the duration of the block as well as for sedation and

analgesia. There are multiple studies comparing the effects of dexmedetomidine given intravenously and perineurally in supraclavicular brachial plexud blocks. A route other than intravenous injection or a low dose may help minimize cardiovascular risks such as bradycardia and hypotension associated with dexmedetomidine. However, few studies have addressed the clinical effects of low-dose intramuscular dexmedetomidine as premedication- and those studies were done in comparison to general anesthesia or in pediatric age group. This research question aims to bridge the existing gaps in literature as it compares the efficacy intramuscular and perineural dexmedetomidine in supraclavicular blocks in adults.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 60

Inclusion Criteria

All the patients undergoing elective and emergency upper limb surgeries under ultrasound-guided supraclavicular brachial plexus block with the American Society of Anaesthesiologists (ASA) physical status 1 and 2.

Exclusion Criteria

Patient refusal.
History of allergic medications used in the study.
Patients with difficulty in communication.
Underlying conditions- bleeding disorders, local infection, existing brachial plexus deficits.
History of treatment for a chronic pain condition/ psychiatric disorder.
Pregnant women.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Onset and duration of sensory blockade	From the time of administration of study drug- every 5 minutes till 30 minutes, every 30 \| minutes till 2 hours, every 4 hours till 12 hours and then every 6 hours up to 24 hours.
Onset and duration of motor blockade	From the time of administration of study drug- every 5 minutes till 30 minutes, every 30 \| minutes till 2 hours, every 4 hours till 12 hours and then every 6 hours up to 24 hours.

Secondary Outcome Measures

Name	Time	Method
Time taken for rescue analgesia	Sedative effect

Trial Locations

Locations (1): Kasturba Hospital Manipal
🇮🇳
Udupi, KARNATAKA, India
Kasturba Hospital Manipal
🇮🇳Udupi, KARNATAKA, India
DR SANJANA S
Principal investigator
9952612396
sanjanasubbiah44@gmail.com