Comparison of dexmedetomidine in ultrasound guided supraclavicular brachial plexusblock versus intramuscular administration in upper limb surgeries.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Onset and duration of sensory blockade
研究概览
简要总结
Supraclavicular brachial plexus blocks are commonly administered in upper limb surgeries. Adjuvants such as dexmedetomidine, clonidine, dexamethasone etc are added in the block to prolong the duration of the block as well as for sedation and
analgesia. There are multiple studies comparing the effects of dexmedetomidine given intravenously and perineurally in supraclavicular brachial plexud blocks. A route other than intravenous injection or a low dose may help minimize cardiovascular risks such as bradycardia and hypotension associated with dexmedetomidine. However, few studies have addressed the clinical effects of low-dose intramuscular dexmedetomidine as premedication- and those studies were done in comparison to general anesthesia or in pediatric age group. This research question aims to bridge the existing gaps in literature as it compares the efficacy intramuscular and perineural dexmedetomidine in supraclavicular blocks in adults.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •All the patients undergoing elective and emergency upper limb surgeries under ultrasound-guided supraclavicular brachial plexus block with the American Society of Anaesthesiologists (ASA) physical status 1 and 2.
排除标准
- •Patient refusal.
- •History of allergic medications used in the study.
- •Patients with difficulty in communication.
- •Underlying conditions- bleeding disorders, local infection, existing brachial plexus deficits.
- •History of treatment for a chronic pain condition/ psychiatric disorder.
- •Pregnant women.
结局指标
主要结局
Onset and duration of sensory blockade
时间窗: From the time of administration of study drug- every 5 minutes till 30 minutes, every 30 | minutes till 2 hours, every 4 hours till 12 hours and then every 6 hours up to 24 hours.
Onset and duration of motor blockade
时间窗: From the time of administration of study drug- every 5 minutes till 30 minutes, every 30 | minutes till 2 hours, every 4 hours till 12 hours and then every 6 hours up to 24 hours.
次要结局
- Time taken for rescue analgesia(Sedative effect)