MRI for the Non-invasive Determination of Renal Blood Flow and Renal Oxygenation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Measurement of Renal Blood Flow of the Kidney by the PAH Method
研究概览
简要总结
Comparison of renal blood flow measurements by PAH clearance and MRI
详细描述
The traditional measurement of renal blood flow in ml/min involves the collection of multiple blood and urine samples after an infusion of a drug called para-aminohippurate (PAH) is given. In this study, the investigators determine the ability of MRI to estimate renal blood flow. The primary hypothesis is that renal blood flow as measured by PAH clearance is similar to renal blood flow as estimated by MRI. The measurements by PAH clearance and MRI are both performed on the same day.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •In this study, the investigators will enroll 16 men and women aged ≥ 18 years with Stage II - V chronic kidney disease (CKD). In addition, the investigators will enroll 4 subjects with a glomerular filtration rate (GFR) of greater than 60 ml/min who do not have any evidence of CKD.
排除标准
- •This study excludes those not suitable for MRI or for the interventional pharmacologic procedures.
研究组 & 干预措施
PAH
PAH measure of renal blood flow is first performed on subjects prior to administration of furosemide
干预措施: Placebo (Other)
MRI after furosemide
After the PAH measurement is complete, subjects receive 20 mg furosemide and undergo BOLD MRI to estimate renal blood flow
干预措施: Furosemide (Drug)
结局指标
主要结局
Measurement of Renal Blood Flow of the Kidney by the PAH Method
时间窗: Renal blood flow is estimated over 1 hour by PAH
Renal blood flow is estimated by the PAH method.
次要结局
- Measurement of Regional Blood Oxygenation by MRI(One measure after furosemide (day 1))