Changes of Regional Tissue Oxygenation Saturation After Successful Femoral Nerve Block

Completed

• Conditions: Anesthesia, Local
• Interventions: Device: tissue oxygenation saturation

• Registration Number: NCT03753594
• Lead Sponsor: Huazhong University of Science and Technology

Brief Summary

Regional tissue oxygenation saturation has been shown to increase in innervated regions after sympathetic block. The aim of this prospective observational study was to evaluate the changes of regional tissue oxygenation saturation by near-infrared spectroscopy after successful femoral nerve block with ropivacaine and determine whether the changes of regional tissue oxygenation saturation can be affected by the concentration of ropivacaine.

Detailed Description

Successful peripheral nerve blocks induce sympathetic blockade, which increases local blood flow by vasodilation. The relationship between successful femoral nerve block and the variation of regional tissue oxygenation saturation was unclear.

Study Timeline

• Study First Submitted: 2018-11-20
• Study First Submitted QC: 2018-11-22
• Study First Posted: 2018-11-27
• Study Start: 2018-11-30
• Status Verified: 2019-05
• Primary Completion: 2019-05-10
• Study Completion: 2019-05-10
• Last Update Submitted: 2019-05-10
• Last Update Posted: 2019-05-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Informed consent
• American Society of Anesthesiologists physical statusⅠ-Ⅱ
• Undergo elective elective knee arthroscopy with peripheral nerve block

Exclusion Criteria

• Refusal to participate in the study
• BMI>35
• Any contraindications to peripheral nerve block such as coagulation abnormalities, •Allergy to local anaesthetics, peripheral neuropathy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
H group	tissue oxygenation saturation	Patients scheduled for elective knee arthroscopy with peripheral nerve block will receive ultrasound-guided femoral nerve block with 0.5% ropivacaine. Regional tissue oxygenation saturation of the nerve innervation area and pinprick sensory tests at 5 min were assessed before the block and at 5-min intervals till 30 min after the block.
L group	tissue oxygenation saturation	Patients scheduled for elective knee arthroscopy with peripheral nerve block will receive ultrasound-guided femoral nerve block with 0.25% ropivacaine. Regional tissue oxygenation saturation of the nerve innervation area and pinprick sensory tests were assessed at 5 min before the block and at 5-min intervals till 30 min after the block.

Primary Outcome Measures

Name	Time	Method
Regional tissue oxygenation saturation after successful femoral nerve block	at 5-minute intervals till 30 minutes after regional block	rSO2

Secondary Outcome Measures

Name	Time	Method
Pinprick sensory scores	5 minute before regional block and at 5-minute intervals till 30 minutes after regional block	A 3-level scale was used to grade the intensity of sensory block using pinprick stimulation: 0=normal sensation; 1=analgesia; 2=anesthesia.

Trial Locations

Locations (1)

Union Hospital; 🇨🇳 Wuhan, Hubei, China