CTIS2024-513530-37-00
Active, not recruiting
Phase 1
Comparison of an inhaled sedation strategy with an intravenous sedation strategy in intensive care patients treated with invasive mechanical ventilation: INASED study - 29BRC19.0280
Overview
- Phase
- Phase 1
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Centre Hospitalier Regional Et Universitaire De Brest
- Enrollment
- 250
- Status
- Active, not recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patient aged 18 and over, Patient requires mechanical ventilation for at least 24 hours, Patient requires immediate continuous sedation for comfort, safety and to facilitate the administration of life\-sustaining measures., Consent obtained from patient or relative
Exclusion Criteria
- •Patient admitted for the following reasons : \- Cardiac arrest \- Refractory status epilepticus \- Moderate to severe head trauma \- Cerebrovascular accident, Minors, Pregnant or breast\-feeding women, Patient not affiliated to the social security system, Auditory or visual impairment, or aphasia prior to inclusion, making CAM\-ICU impossible to perform, Sedation for more than 24 hours, Impaired cognitive function and/or dementia, Contraindication to halogenated gas (personal or family history of malignant hyperthermia, acute or chronic neuromuscular disease, hepatocellular insufficiency with TP\<30%), Severe ARDS (Berlin criteria: PaO2/FiO2\<100 after ventilatory optimization), PaCO2 at inclusion \> 50 mmHg with pH\<7\.2 after ventilatory optimization, Patient for whom a limitation of active therapies procedure is envisaged on inclusion, Patient under guardianship or curatorship
Outcomes
Primary Outcomes
Not specified
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