Comparison of an inhaled sedation strategy with an intravenous sedation strategy in intensive care patients treated with invasive mechanical ventilation: INASED study - 29BRC19.0280

Centre Hospitalier Regional Et Universitaire De Brest0 个研究点目标入组 250 人开始时间: 2024年7月31日最近更新: 2024年8月21日

适应症

试验速览

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•Patient aged 18 and over, Patient requires mechanical ventilation for at least 24 hours, Patient requires immediate continuous sedation for comfort, safety and to facilitate the administration of life-sustaining measures., Consent obtained from patient or relative

•Patient admitted for the following reasons : - Cardiac arrest - Refractory status epilepticus - Moderate to severe head trauma - Cerebrovascular accident, Minors, Pregnant or breast-feeding women, Patient not affiliated to the social security system, Auditory or visual impairment, or aphasia prior to inclusion, making CAM-ICU impossible to perform, Sedation for more than 24 hours, Impaired cognitive function and/or dementia, Contraindication to halogenated gas (personal or family history of malignant hyperthermia, acute or chronic neuromuscular disease, hepatocellular insufficiency with TP<30%), Severe ARDS (Berlin criteria: PaO2/FiO2<100 after ventilatory optimization), PaCO2 at inclusion > 50 mmHg with pH<7.2 after ventilatory optimization, Patient for whom a limitation of active therapies procedure is envisaged on inclusion, Patient under guardianship or curatorship

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