Adapted modified Toronto Clinical Neuropathy Score validated by quantitative sensory testing and nerve conduction studies for renal transplant recipients

Completed

Conditions: peripheral nervous system disease
polyneuropathy
10034606

Registration Number: NL-OMON54903

Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 205

Inclusion Criteria

All >=18 years of age
Patient is able to understand the Dutch language and capable to intellectually
comprehend questionnaires and physical tests
Signed and dated informed consent prior to any study-related procedures
Previous participation in the TransplantLines cohort study and biobank

Exclusion Criteria

Patient refusal
Amputation of lower or upper limb(s) bilaterally, trauma of limbs
Patients with a pacemaker or ICD
Use of mind-altering drugs in previous 24 hours
Metal osteosynthesis after bone fracture (in arms or legs)
Patients with mononeuropathies in examined nerves

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study endpoint is to validate the amTCNS result with quantitative<br /><br>sensory testing and nerve conduction studies.<br /><br>The following endpoints will be included:<br /><br>1. amTCNS result (score between 0 and 30)<br /><br>2. Quantitative sensory testing: thermal threshold testing<br /><br>3. Nerve conduction studies: SNAP amplitude, CMAP amplitude and distal motor<br /><br>latency, nerve conduction velocity, H-reflex</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>In addition to the amTCNS, temperature sense, muscle strength and reflexes will<br /><br>be examined to assess whether they should be included in the amTCNS for a<br /><br>better specificity and sensitivity of the score for quantifying the severity of<br /><br>polyneuropathy.</p><br>