Split or Whole Liver Transplantation? A Multicenter Retrospective Cohort Study of Patients With Benign and Malignant Liver Disease
- Conditions
- Zhejiang University
- Registration Number
- NCT06359496
- Lead Sponsor
- Zhejiang University
- Brief Summary
The primary objective of this study was to assess the safety and feasibility of split liver transplantation(SLT) for adult hepatocellular carcinoma (HCC) patients, while comparing the prognostic disparities between adult SLT and WLT also .
Liver transplantation (LT) is an effective treatment for end-stage liver disease. As a traditional marginal donor liver, the application of SLT in pediatric patients is successful.However, its application in adult liver transplantation, especially in HCC patients, remains controversial.
This retrospective study analyze outcomes among adults who underwent SLT and whole liver transplantation (WLT) at two centers from January 2018 to August 2022. A 1:1 propensity score matching (PSM) analysis was performed based on important donor and recipient variables. Baseline characteristics and postoperative outcomes of the above recipients were analyzed and compared. Statistical significance was determined using a two-sided p-value threshold of less than 0.05.
- Detailed Description
The primary objective of this study was to assess the safety and feasibility of split liver transplantation(SLT) for adult hepatocellular carcinoma (HCC) patients, while comparing the prognostic disparities between adult SLT and WLT also .
Liver transplantation (LT) is an effective treatment for end-stage liver disease. As a traditional marginal donor liver, the application of SLT in pediatric patients is successful.However, its application in adult liver transplantation, especially in HCC patients, remains controversial.
This retrospective study analyze outcomes among adults who underwent SLT and whole liver transplantation (WLT) at two centers from January 2018 to August 2022. A 1:1 propensity score matching (PSM) analysis was performed based on important donor and recipient variables. Baseline characteristics and postoperative outcomes of the above recipients were analyzed and compared. Statistical significance was determined using a two-sided p-value threshold of less than 0.05.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1
- ≥ 18 years old
- Received a liver transplantation between 2018 and 2022 (3) Liver transplantation was performed by SLT or WLT
- Re-LT
- Multiorgan transplantation
- Survival≤one week after LT
- Incomplete data
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Postoperative complications were evaluated by postoperative imaging reports and serological indicators Jan.1 2018-Dec.31 2022 Including rejection, emerging metabolic diseases, infections
The survival rate of each group was evaluated by follow-up survey and K-M curve Jan.1 2018-Dec.31 2022 Including overall survival rate and/or tumor free survival rate
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Xiao Xu
🇨🇳Hangzhou, China