Comparison of magnesium sulfate and lidocaine nebulization on attenuation of hemodynamic responses to laryngoscopy and endotracheal intubation
试验速览
- 阶段
- 2/3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 106
- 试验地点
- 1
- 主要终点
- Nebulised MgSO4 tends to show superior or comparable attenuation of hemodynamic responses compared to nebulised lidocaine.
研究概览
简要总结
This randomised controlled trial will compare the effect of nebulisation of MgSO4 and lidocaine on attenuating hemodynamic response during laryngoscopy and endotracheal intubation in ASA grade 1 and 2 patients undergoing elective surgery. A total of 106 patients will be selected based on inclusion and exclusion criteria. Vital parameters, such as HR, BP, and SPO2, will be measured at various time points, like baseline, post-nebulisation, post-induction, 1, 2, 5, and 10 minutes post-laryngoscopy and intubation. The efficacy of both drugs in attenuating the hemodynamic response will be compared.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Day(s) 至 65.00 Day(s)（—）
- 性别
- All
入选标准
- •Patients aged between 18 and 6 5 years, American Society o f Anesthesiologists physical status I and II, scheduled for elective surgeries under general anaesthesia requiring endotracheal intubation will be included in this study.
排除标准
- •pregnancy and lactation, Hypersensitivity to two study drugs, and an anticipated difficult airway , History of reactive airway diseases hypertension, Patients with cardiovascular dysfunction & arrhythmias, Patients with raised ICP, IOP, any neuromuscular disorder, Patients who received epidural or spinal before general anaesthesia.
结局指标
主要结局
Nebulised MgSO4 tends to show superior or comparable attenuation of hemodynamic responses compared to nebulised lidocaine.
时间窗: Nebulised MgSO4 tends to show superior or comparable attenuation of hemodynamic responses compared to nebulised lidocaine.
次要结局
未报告次要终点
研究者
SAURAV KUMAR
VMMC & Safdarjung hospital