Aggressive Antipyretics for Fever Reduction in CNS Malaria

Not Applicable

• Conditions: Malaria; Paediatrics

• Registration Number: PACTR201804003255157
• Lead Sponsor: niversity of Rochester

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-03-27
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 284

Inclusion Criteria

1. Evidence of P. falciparum malaria infection by peripheral blood smear or rapid diagnostic test.
2. CNS symptoms associated with malaria. Cerebral malaria: Impaired consciousness with a Blantyre Coma Score (BCS)(73)less than or equal to 2 in children under 5 yrs or a Glasgow Coma Score (GCS)less than or equal to 10 in children greater than or equal to 5 yrs OR CNS MALARIA: Complicated seizure(s), meaning prolonged (>15 minutes), focal or multiple; or impaired consciousness or other evidence of impaired consciousness (confusion, delirium) without frank coma (BCS>2,GCS=11-14).

Exclusion Criteria

1. Circulatory failure (cold extremities, capillary refill > 3 seconds, sunken eyes, decreased skin turgor).
2. Vomiting in the past 2 hrs.
3. Serum Cr> 1.2 mg/dL.
4. A hx of liver disease.
5. Jaundice or a total bilirubin of >3.0mg/dL.
6. A hx of gastric ulcers or gastrointestinal bleeding.
7. A hx of thrombocytopenia or other primary hematologic disorder.
8. Petechiae or other clinical indications of bleeding abnormalities.
9. A known allergy to ibuprofen, acetaminophen, aspirin or any non-steroidal medication.
10. Any contraindication for nasogastric tube (NGT) placement and/or delivery of enteral medications.

Study & Design

• Study Type: Interventional
• Study Design: Not specified