PACTR201804003255157已完成未知
Aggressive Antipyrectics in CNS Malaria: A Randomized-Controlled Trial Assessing Antipyretic Efficacy and Parasite Clearance Effects
niversity of Rochester0 个研究点目标入组 284 人开始时间: 2018年3月27日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 284
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 2 Year(s) 至 11 Year(s)（—）
- 性别
- All
入选标准
- •1. Evidence of P. falciparum malaria infection by peripheral blood smear or rapid diagnostic test.
- •2. CNS symptoms associated with malaria. Cerebral malaria: Impaired consciousness with a Blantyre Coma Score (BCS)(73)less than or equal to 2 in children under 5 yrs or a Glasgow Coma Score (GCS)less than or equal to 10 in children greater than or equal to 5 yrs OR CNS MALARIA: Complicated seizure(s), meaning prolonged (>15 minutes), focal or multiple; or impaired consciousness or other evidence of impaired consciousness (confusion, delirium) without frank coma (BCS>2,GCS=11-14).
排除标准
- •1. Circulatory failure (cold extremities, capillary refill > 3 seconds, sunken eyes, decreased skin turgor).
- •2. Vomiting in the past 2 hrs.
- •3. Serum Cr> 1.2 mg/dL.
- •4. A hx of liver disease.
- •5. Jaundice or a total bilirubin of >3.0mg/dL.
- •6. A hx of gastric ulcers or gastrointestinal bleeding.
- •7. A hx of thrombocytopenia or other primary hematologic disorder.
- •8. Petechiae or other clinical indications of bleeding abnormalities.
- •9. A known allergy to ibuprofen, acetaminophen, aspirin or any non-steroidal medication.
- •10. Any contraindication for nasogastric tube (NGT) placement and/or delivery of enteral medications.
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