Do hippocampus, insula and amygdala contribute to an anxiety syndrome biomarker in healthy participants and patients with anxiety disorder when given anxiolytic medications?

niversity of Otago0 个研究点目标入组 300 人开始时间: 2020年11月16日最近更新: 2021年7月12日

适应症

试验速览

暂无简介。

•We will recruit healthy participants.
•Inclusion Criteria:
•1.Capable of understanding and signing an informed consent
•2.Aged 18-40 years on the day of consent.
•3.Volunteers with no major illness in the previous 30 days
•4.With no regular use of psychotropic medication in the last 12 months
•5.No use of alcohol in the 24 hours before testing
•For the clinical comparison, patients with DSM-5 generalized anxiety (GAD); and social anxiety disorder (SAD) will be recruited for our project
•Inclusion Criteria:
•1. 18-40 years old
•2. suffering from ongoing symptoms of anxiety, fear, or panic and who are intending to seek treatment for this
•3. otherwise be healthy (with no major illness in the previous 30 days)
•4. with no regular use of psychotropic medication in the last 6 months and
•5. no use of alcohol in the 24 hours before testing.

•Healthy Volunteers:
•Exclusion Criteria:
•- Susceptibility to photosensitivity
•- A history of seizure
•- Any metal in your body, e.g., cardiac pacemaker, cochlea implant, intracranial vessel clips, artificial heart valve or vascular stent; a history of metal fragments in the eye; shrapnel within the body
•- Are either pregnant or think you might be
•- A history of claustrophobia
•- Have received any medical or psychological treatment for anxiety, depression or emotional disorder within the last 12 months.
•- Have a prior history of drug abuse
•- Are suffering from acute or chronic physical disease such as heart and lung disease, influenza, diabetes, acute infections
•- Are recovering from an accident, injury or operation.
•Patient Volunteers (GAD and SAD)
•Exclusion Criteria:
•- Susceptibility to photosensitivity
•- A history of seizure
•- Any metal in your body, e.g., cardiac pacemaker, cochlea implant, intracranial vessel clips, artificial heart valve or vascular stent; a history of metal fragments in the eye; shrapnel within the body
•- Are either pregnant or think you might be
•- A history of claustrophobia
•- Have a prior history of drug abuse
•- Are suffering from acute or chronic physical disease such as heart and lung disease, influenza, diabetes, acute infections
•- Are recovering from an accident, injury or operation.

发起方