Acute Ventilatory Response to Hypoxia During Sedation With Dexmedetomidine Compared to Propofol in Healthy Male Volunteers
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 11
- 试验地点
- 2
- 主要终点
- Hypoxic ventilatory response
研究概览
简要总结
The overall aim with this project is to investigate the effect of dexmedetomidine on control of breathing in healthy volunteers and to compare it with propofol at the same degree of sedation.
详细描述
15 volunteers will be investigated for their hypoxic and hypercapnic ventilatory response during sedation with dexmedetomidine and propofol in a randomized cross-over study.
6 volunteers will be investigated for their repeated response to hypoxia and hypercapnia in order to validate the method.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •American Society of Anesthesiologist´s classification (ASA) 1, i.e. healthy
- •No medication
- •No allergies
- •Non-smoker/no snuff, i.e. no nicotine intake
- •Normal weight, BMI <26
排除标准
- 未提供
结局指标
主要结局
Hypoxic ventilatory response
时间窗: One day for each drug; before,during and after sedation with dexmeditomidine or propofol
Acute hypoxic ventilatory response,i.e. the ventilatory response to acute hypoxia measured as change in minute ventilation over change in peripheral oxygen saturation
次要结局
- hypercapnic ventilatory response(One day for each drug; Before, during and after sedation with dexmedetomidine or propofol)
研究者
Malin Jonsson Fagerlund
MD, PhD
Karolinska University Hospital