Intranasal Dexmedetomidine versus Intranasal Butorphanol in attenuation of haemodynamic response during laryngoscopy and intubation.

Haemodynamic response during laryngoscopy & intubation may lead to serious consequences specially in hypertensive, coronary artery disease patients and in patients having myocardial ischemia, intracranial aneurysm. Till date, no single method is an ideal in attenuation of haemodynamic response during laryngoscopy & intubation. Moreover, use of intravenous agents have more side effect profile as compared to other routes of administration.

Intranasal administration of drugs can be as useful as intravenous route with less adverse effects and have been used in various studies. Both the study drugs have been used individually or in combination with other drugs via intranasal route. But, no previous studies have compared dexmedetomidine and butorphanol via intranasal route prior to administration of general anaesthesia.

So, with the help of this study, we will be able to conclude that whether intranasal dexmedetomidine or intranasal butorphanol can be used to attenuate haemodynamic response and also will come to know which drug is better in attenuating haemodynamic response during laryngscopy & intubation with less side effects between two drugs.