NCT03795155Unknown不适用
Prospective Genomics Initiative on Multiple Synchronous Lung Cancer (PGI-MSLC)
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Genomic characters of synchronous lessions in each MSLC patient
研究概览
简要总结
This prospective study is to characterize the genomic landscape and genetic heterogeneity of multiple synchronous lung cancer (MSLC) in correlation with comprehensive clinical, histopathological and medical imaging information, in order to improve disease diagnosis and tailored treatment for MSLC patients.
详细描述
- To initiate a prospective registry of MSLC patients with high-quality clinical samples and detailed medical data.
- To define the clonal relationship, genomic landscape and potential driver alterations of MSLC using whole-genome sequencing.
- To determine the intrapatient and intratumor genetic heterogeneity of MSLC.
- To correlate molecular features with clinical parameters and patient outcome.
- To serve as a continuous infrastructure for a large variety of research purposes including: A. Diagnostic research B. Prognostic research C. Biological research D. Interventional trial design testing new therapies in MSLC.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18 years or older
- •Confirmed diagnosis of multiple synchronous lung cancers (MSLCs) without metastatic disease
- •Signed informed consent
排除标准
- •Medical or psychiatric condition that would preclude informed consent
- •History of known high-risk infections
- •With metastatic tumors except lung
结局指标
主要结局
Genomic characters of synchronous lessions in each MSLC patient
时间窗: November 30, 2021
Whole-genome sequencing reveals the mutation, copy number variation and structure variation of MSLCs. We will analysis the genomic characters of synchronous lesions in each MSLC patient.
次要结局
未报告次要终点
研究者
研究点 (1)
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