Ketamine for analgesia in mechanically ventilated adults

Phase 2

Recruiting

• Conditions: Pain; Mechanical ventilation; Anaesthesiology - Other anaesthesiology; Anaesthesiology - Pain management

• Registration Number: ACTRN12622000920796
• Lead Sponsor: Austin Health

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-06-28
• Last Update Posted: 26 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 125

Inclusion Criteria

Equal to or greater than 18 years of age
Mechanically ventilated at the time of assessment for eligibility
Opioid medication infusion prescribed by treating intensive care unit physician
Enrolment to occur within the first 12 hours of intensive care unit admission

Exclusion Criteria

Cardiac surgical patients
Previous adverse reaction to ketamine
Equal to or older than 80 years of age
Pregnancy or lactation
Uncontrolled hypertension defined as systolic blood pressure of greater than 180 millimeters of mercury
Uncontrolled heart failure
Patients admitted to intensive care for end-of-life care or to facilitate organ donation
Previous enrolment in the KALME trial
No legal surrogate identified or able to provide informed consent to continue for patient

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Total administered opioid dose[ From the date of first index intensive care unit admission through to intensive care unit discharge as measured as fentanyl or fentanyl equivalents using ratio of fentanyl: morphine of 10 micrograms:550micrograms, as recorded in the medication charts, electronic medical records or observation charts.]