Evaluation of Anterior Cruciate Ligament Tears Using Diffusion Tractography

Not Applicable

Recruiting

• Conditions: Tractography; MRI; ACL Injury

• Registration Number: NCT05806034
• Lead Sponsor: Centre Hospitalier Universitaire, Amiens

Brief Summary

Knees injuries commonly affect the ACL. French current methodology is based on MRI focused on the knee with morphological sequences (T1, DP fat sat) allowing the study of ACL as follows: No lesion / Partial tear / Complete tear.

The treatment (kinesitherapy, surgery, no intervention) is defined taking into account several factors such as age, knee laxity, physical activity and outcome of the radiology analysis (partial or complete tear). However, if the classification is straightforward in case of complete tear, it is not possible to establish a quantitative impact on the ACL in case of partial tear. As a consequence, the investigators will analyze the anisotropy coefficient with diffusion tractography. Any patient who undergo a posttraumatic knee MRI at the CHU Amiens Picardie will have an appointment at the 3T "Signa" MRI that has the knee-centric diffusion tractography sequence.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-12-08
• Status Verified: 2023-03
• Study First Submitted: 2023-03-28
• Study First Submitted QC: 2023-03-28
• Last Update Submitted: 2023-03-28
• Study First Posted: 2023-04-10
• Last Update Posted: 2023-04-10
• Primary Completion: 2024-03
• Study Completion: 2024-03

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 297

Inclusion Criteria

• Age ≥ 18 years old,
• Patient referred for non-enhanced knee MRI for traumatism.
• Affiliation to a social security program,

Exclusion Criteria

• Person under guardianship or curators,
• Any contraindications to MRI

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Correlation between anisotropy coefficient and ACL lesion state	one year	Anisotropy coefficient value is between 0 (isotropic medium) to 1 (fibrillar medium) .; Anisotropy coefficient =0 is for total ACL rupture ACL lesion state are No lesion, Partial tear or Complete tear
Anisotropy score after tractography MRI sequence	one day	Anisotropy coefficient value is between 0 (isotropic medium) to 1 (fibrillar medium) .; Anisotropy coefficient =0 is for total ACL rupture Anisotropy coefficient between 0 end 0.8 is for partial ACL rupture

Trial Locations

Locations (1)

CHU Amiens Picardie; 🇫🇷 Amiens, France