Insulinotropic Effect of GIP and GLP-1 Before and After Reduced Glucose Induced by Steroid Treatment, Relative Physical Inactivity and High Calorie Diet
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 10
- 试验地点
- 2
- 主要终点
- Insulinotropic effect of incretin hormones
研究概览
简要总结
The incretin effect in patients with type two diabetes is reduced. The investigators have previously shown that it is possible to induce a defect in the incretin effect in healthy individuals. The purpose of this study is to evaluate the insulinotropic affect of the incretin hormones in healthy individuals before and after a deterioration of the glucose homeostasis.
详细描述
The incretin effect in patients with type two diabetes is reduced. The investigators have previously shown that it is possible to induce a defect in the incretin effect in healthy individuals. The purpose of this study is to evaluate the insulinotropic affect of the incretin hormones in healthy individuals before and after a deterioration of the glucose homeostasis. The evaluation is done by infusing GIP, GLP-1 or saline during hyperglycemic clamps.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Caucasians without type 2 diabetes mellitus
- •Normal OGTT (75 g of glucose) according to WHO's criteria
- •BMI 20-30
- •Hemoglobin > 8.0 mmol/l
- •Informed consent
排除标准
- •Liver disease (ALAT > 2 x normal level)
- •Nephropathy (s-creatinin > 130 µM or albuminuria)
- •Relatives (parents/siblings) with T2DM
- •Medical treatment witch cannot be stopped for 12 hours
结局指标
主要结局
Insulinotropic effect of incretin hormones
时间窗: 12 days
Measurements of the insulinotropic effect of incretin hormones before and after 12 days intervention with steroid treatment, high calorie diet and relative physical inactivity
次要结局
- Plasma concentration of glucagon(12 days)