跳至主要内容
临床试验/NCT07345975
NCT07345975招募中不适用

Characterization of Opposition to Organ Donation at Strasbourg University Hospital in 2024-2025

University Hospital, Strasbourg, France1 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2025年10月14日最近更新:

试验速览

阶段
不适用
状态
招募中
发起方
入组人数
100
试验地点
1
主要终点
Distribution of positions regarding organ donation (certain, uncertain, unknown)

研究概览

简要总结

In 2024, 29,000 people are waiting for organ transplants in France, and only 6,034 transplants were performed during the year. 852 people died while waiting for a transplant. The gap between the number of available transplants and the number of patients waiting for transplants has been widening since the 1990s; there is talk of a shortage of transplants. There is therefore an urgent need to find more transplants and mobilize the entire population to this end.

French law supports presumed consent, meaning that we are all donors unless we have expressed otherwise during our lifetime. In fact, 80% of French people say they are in favor of organ donation after their death, but few discuss it with their loved ones. When families are approached about multi-organ removal to gather any opposition from the deceased, the refusal rate is 37% (compared to an expected 20%).

It is difficult to determine whether this opposition truly comes from the deceased themselves, their loved ones, uncertainty, or the situation. As this is the leading cause of non-donation, it is essential to better characterize this opposition in order to reduce it and allow for more organ donation and, ultimately, transplantation.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Patients who are brain dead and/or eligible for a Maastricht 3 protocol (discontinuation of active treatment with death due to circulatory arrest in intensive care)
  • Hospitalized in the intensive care unit of the Strasbourg University Hospital or transferable to the Strasbourg University Hospital for multi-organ removal (anticipated approach)
  • Existence of relatives with whom discussion is possible
  • Presence of organ procurement coordination at the initial donation interview

排除标准

  • Absence of relatives of the deceased (no interview with them)
  • Absence of organ procurement coordination during the initial discussion with relatives regarding organ and tissue procurement

结局指标

主要结局

Distribution of positions regarding organ donation (certain, uncertain, unknown)

时间窗: Up to 12 months

Distribution of positions regarding organ donation (certain, uncertain, unknown): For illustration purposes: * Certain position: ≈ 65% * Favorable: ≈ 55% * Opposed: ≈ 10% * Uncertain position: ≈ 25% * Unknown/unexpressed position: ≈ 10%

次要结局

未报告次要终点

研究者

发起方
University Hospital, Strasbourg, France
申办方类型
Other
责任方
Sponsor

研究点 (1)

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