Prospective Study on Geometric Parameters and Hemodynamic Reference Range of Neonatal Heart.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Echocardiography of Newborns
- Sponsor
- Peking University Third Hospital
- Enrollment
- 400
- Locations
- 1
- Primary Endpoint
- Reference range of cardiac geometric parameters of preterm infants based on different gestational ages, weights, days of age and body surface area.
- Last Updated
- 6 years ago
Overview
Brief Summary
Perform bedside echocardiography on neonates (term and preterm infants) who were admitted to our neonatal department within 24 hours of birth, and establish a geometric reference range of neonatal cardiac ultrasound and explore the hemodynamic changes of early newborns.
Bedside echocardiography were performed to measure the diameter of each heart cavity and large vessels, velocity of each valve and aorta, wall thickness, left ventricular systolic function, right heart Tei index, Tricuspid Annular Plane Systolic Excursion(TPASE) of term and preterm infants respectively on 0 day, 3d, 7d of life and postmenstrual age of 30 weeks, 32 weeks, 34 weeks and 36 weeks.
Investigators
Dan Fang Lu
Attending physician
Peking University Third Hospital
Eligibility Criteria
Inclusion Criteria
- •Infants with normal hearts (infants with small patent fora-men oval or small patent ductus arteriosus were not excluded).
- •2.Healthy preterm infant with no evidence of sepsis, renal failure.
- •Absence of other major congenital anomalies or syndromes
- •Prior written consent was obtained from the parents.
Exclusion Criteria
- •Infants with severe congenital malformations, either cardiac or non-cardiac.
Outcomes
Primary Outcomes
Reference range of cardiac geometric parameters of preterm infants based on different gestational ages, weights, days of age and body surface area.
Time Frame: 0 day of life to PMA 36 weeks
Hemodynamic changes in full-term and preterm infants on 0~7days of life.
Time Frame: 0~7days of life
Secondary Outcomes
- Reference range of cardiac geometric parameters of full-term infants based on different weights, days of age and body surface area.(0~7days of life)