Dichloroacetate Kinetics, Metabolism and Toxicology

Completed

• Conditions: Lactic Acidosis

• Registration Number: NCT00015015
• Lead Sponsor: National Institute of Environmental Health Sciences (NIEHS)

Brief Summary

Dichloroacetate (DCA) is a product of water chlorination and a metabolite of certain industrial solvents, thus making it a chemical of environmental concern. However, DCA is also used as an investigational drug for treating various diseases of adults and children, at doses far greater than those to which humans are normally exposed in the environment. Our research involves how DCA is metabolized by healthy adults and by children with a fatal genetic disease, congenital lactic acidosis (CLA) who are treated with DCA.

Detailed Description

Not available

Study Timeline

• Study Start: 1994-12
• Study First Submitted: 2001-04-17
• Study First Submitted QC: 2001-04-18
• Study First Posted: 2001-04-19
• Study Completion: 2002-10
• Status Verified: 2006-09
• Last Update Submitted: 2006-09-01
• Last Update Posted: 2006-09-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Univ. of Florida; 🇺🇸 Gainesville, Florida, United States