Meningioma and Embolism Thrombosis Risk & Investigation of Coagulation

Recruiting

• Conditions: Meningeoma; Thrombembolism; Surgical Resection

• Registration Number: NCT06709833
• Lead Sponsor: University Hospital Tuebingen

Brief Summary

Despite being generally benign tumors, meningiomas are associated with an increased risk for thrombembolic complications after surgical resection. The molecular mechanisms underlying this circumstance are still unknown.

In this prospective observational trial, the investigators aim to evaluate the changes in coagulation and platelet function caused by tumor resection.

Blood samples are obtained by patients undergoing meningioma resection before and immediately after resection to detect said changes.

As a control cohort, blood samples are obtained from patients undergoing resection for glioma.

Detailed Description

Not available

Study Timeline

• Status Verified: 2024-11
• Study First Submitted: 2024-11-25
• Study First Submitted QC: 2024-11-25
• Study First Posted: 2024-11-29
• Study Start: 2024-12-16
• Last Update Submitted: 2025-01-03
• Last Update Posted: 2025-01-06
• Primary Completion: 2025-12-31
• Study Completion: 2026-08-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Patients undergoing resection for meningioma or
• Patients undergoing resection for glioma or
• Healthy controls
• written consent for study participation

Exclusion Criteria

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Tissue factor	duration of surfical tumor resection (a few hours)	Concentration of tissue factor at pre-surgery and immediately after tumor resection (during close-up).

Trial Locations

Locations (1)

University Hospital for Anaesthesiology and Intensive Care Medicine, Tuebingen; 🇩🇪 Tuebingen, Baden-Wuerttemberg, Germany