A Phase Ib/II, Open Label, Multi-center Study Evaluating the Safety and Efficacy of BKM120 in Combination With Trastuzumab in Patients With Relapsing HER2 Overexpressing Breast Cancer Who Have Previously Failed Trastuzumab
试验速览
- 阶段
- 1 期
- 状态
- 终止
- 入组人数
- 72
- 试验地点
- 8
- 主要终点
- Dose Limiting Toxicity (DLT) - Phase l Only
研究概览
简要总结
This study will assess the safety and efficacy of BKM120 in combination with trastuzumab in patients with relapsing HER2 overexpressing breast cancer who have previously failed trastuzumab.
The study will further assess the safety and preliminary efficacy of BKM120 in combination with trastuzumab and capecitabine in patients with relapsing HER2 overexpressing breast cancer and brain metastases (BM) who have previously failed trastuzumab.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •World Health Organization (WHO) Performance Status of ≤ 2
- •Patients with HER2+ breast cancer by local laboratory testing (immunohistochemistry [IHC] 3+ staining or fluorescence in situ hybridization [FISH] confirmation for IHC 2+ and 1+)
- •Documented tumor resistance to trastuzumab:
- •Recurrence while on trastuzumab or within 12 months since the last infusion for patients who received trastuzumab as adjuvant treatment
- •Progression while on or within 4 weeks since the last infusion of trastuzumab for patients who received trastuzumab for metastatic disease.
- •Documented evidence of progressive disease per Response Evaluation Criteria in Solid Tumors (RECIST) on trastuzumab-based therapy defined as:
- •Phase Ib: at any time before study entry
- •Phase II: within 16 weeks before date of first dosing
- •Received at least 1 but no more than 4 prior anit-HER2 based regimens including at least 1 regimen containing trastuzumab (adjuvant or neo-adjuvant trastuzumab will be considered as one prior regimen). HER2 directed therapies are defined as comprising trastuzumab, lapatinib, and trastuzumab-DM1 (T-DM1) only.
- •Phase II only: trastuzumab, T-DM1 or lapatinib must be part of the most recent line of therapy
- •Previous lines of cytotoxic chemotherapy:
- •Phase Ib: no more than 4 lines of cytotoxic chemotherapy
- •Phase II: no more than 3 lines of cytotoxic chemotherapy
- •Measurable disease:
- •Phase Ib: patient has at least one measurable lesion or non-measurable disease as defined per RECIST
- •Phase II: patient has at least one measureable lesion as defined per RECIST
- •|| Specific Inclusion Criteria for patients in BM cohorts:
- •Patient has evidence of progressing brain metastases and/or new metastatic brain lesion(s) without leptomeningeal disease.
- •Patient has received prior WBRT and/or SRS at at >28 and >/= 14 days, respectively, prior to starting study drug and the patient must have recovered from the side effects of the therapy
- •WHO performance status of </=1
- •PT INR </= 1.5
- •Any number of prior HER2-directed and cytotoxic regimens, and the most recent line may be any type of anti-neoplastic therapy
排除标准
- •Patients with untreated brain metastases
- •Patients with acute or chronic liver, renal disease or pancreatitis
- •Patients with any peripheral neuropathy ≥ Common Terminology Criteria for Adverse Events (CTCAE) grade 2
- •Patients with a history of mood disorders or ≥ CTCAE grade 3 anxiety
- •Patient with clinical manifest diabetes mellitus or steroid-induced diabetes mellitus
- •|| Specific Exclusion Criteria for patients in BM cohorts
- •Prior treatment with capecitabine
- •Patient has known dihydropyrimidine dehydrogenase (DPD) deficiency
- •Patient is currently receiving treatment with EIAED
- •Other protocol-defined inclusion/exclusion criteria may apply
研究组 & 干预措施
HER2+ metastatic breast cancer
Patients with HER2-overexpressing metastatic breast cancer, with or without PIK3 signaling pathway alteration, who have previously failed trastuzumab
干预措施: BKM120 (Drug)
HER2+ metastatic breast cancer
Patients with HER2-overexpressing metastatic breast cancer, with or without PIK3 signaling pathway alteration, who have previously failed trastuzumab
干预措施: Trastuzumab (Drug)
HER2+ metastatic breast cancer with BM
Patients with HER2-overexpressing metastatic breast cancer and brain metastases, with or without PIK3 signaling pathway alteration, who have previously failed trastuzumab
干预措施: BKM120 (Drug)
HER2+ metastatic breast cancer with BM
Patients with HER2-overexpressing metastatic breast cancer and brain metastases, with or without PIK3 signaling pathway alteration, who have previously failed trastuzumab
干预措施: Trastuzumab (Drug)
HER2+ metastatic breast cancer with BM
Patients with HER2-overexpressing metastatic breast cancer and brain metastases, with or without PIK3 signaling pathway alteration, who have previously failed trastuzumab
干预措施: Capecitabine (Drug)
结局指标
主要结局
Dose Limiting Toxicity (DLT) - Phase l Only
时间窗: cycle 1 - 28 days
Determination of the maximum tolerated dose (MTD) in the dose escalation part of the study was based upon the estimation of the probability of DLT in Cycle 1 in patients of the dose-determining set.
Overall Response Rate (ORR) - Phase ll
时间窗: 18 months
Objective response rate (ORR) was defined as the rate of patients with best overall response (BOR) equal to complete response (CR) or partial response (PR) according to RECIST 1.0 from the Investigators review. Per Response Evaluation Criteria In Solid Tumors (RECIST) version 1.0 assessed of the disease status by imaging (i.e. CT/MRI): Complete Response (CR) = Disappearance of all tumor lesions; Partial Response (PR)= \>=30% shrinkage of lesions; Overall Response (OR) = patients with CR and PR.
次要结局
- Disease Control Rate (DCR) Based on Investigator Assessment- Phase l & ll(18 months)
- Clinical Benefit Rate (CBR) - Phase l & ll(18 months)
- Progression Free Survival (PFS) - Based on Investigator Review Using Kaplan Meier - Phase l & ll(18 months)