A Translation Randodomized Trial of Culturally Specific and Cost Effective Life Style Intervention for the Prevention of Type 2 Diabetes in Pakistan
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Prediabetic State & High Risk Individuals on the Basis of Diabetes Risk Score
- Sponsor
- Aga Khan University
- Enrollment
- 1564
- Locations
- 1
- Primary Endpoint
- Incidence of Type 2 Diabetes
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
The Karachi-based Pakistan Diabetes Prevention Study aims to address key issues in the prevention of type 2 diabetes. Approximately 20,000 people From four communities will be screened for diabetes risk factors using a non-invasive diabetes risk-score system. Those found to be at increased risk will be given an oral glucose tolerance test. People who, after the oral glucose tolerance test, are identified as having prediabetes or normal but with risk factors such as raised BMI and/or history of hypertension will have the opportunity to take part in the Pakistan Diabetes Prevention Study lifestyle intervention. This consists of culturally adjusted preventive strategies focusing on diet and physical activity in real-life settings. Another important aspect of this trial will be to assess the impact of urban planning on the prevalence of obesity and diabetes.
Detailed Description
The aim of this study is to translate the life style intervention project to prevent diabetes into real life settings in Karachi, Pakistan, home to one sixth of the world's population.
Investigators
Dr. Asma Ahmed
Assistant Professor
Aga Khan University
Eligibility Criteria
Inclusion Criteria
- •Adult men and women between 30-64 years of age
Exclusion Criteria
- •Diagnosed type 1 or type 2 diabetes
- •Pregnancy or presence of chronic disease rendering survival for three years unlikely
- •Any psychological or physical disability to interfere with participation in the study
- •Ischemic heart disease
Outcomes
Primary Outcomes
Incidence of Type 2 Diabetes
Time Frame: 2 yrs
Incidence of type 2 diabetes based on OGTT, diagnosed by WHO criteria at interim and end of an intervention.
Secondary Outcomes
- Components of Metabolic syndrome(2 years)
- The impact of city planning on prevalence of obesity and type 2 diabetes(2 years)