Gut Microbiota Profile and Its Impact on Immunity Status in COVID-19 Vaccinated Cohorts
Active, not recruiting
- Conditions
- COVID-19 VaccinationGut Microbiota
- Registration Number
- NCT04980560
- Lead Sponsor
- Chinese University of Hong Kong
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Active, not recruiting
- Sex
- All
- Target Recruitment
- 215
Inclusion Criteria
Inclusion Criteria for Vaccination (VAC) cohort:<br><br> 1. aged = 18 years old; and<br><br> 2. have documented to have no previous COVID-19 infection; and<br><br> 3. will receive any type of COVID-19 vaccines; and<br><br> 4. agree to hand in study samples (stool and blood); and<br><br> 5. agree to sign the informed consent<br><br>Inclusion Criteria for COVID-19 convalescent (CON) cohort:<br><br> 1. aged = 18 years old; and<br><br> 2. recovered from varying severity of COVID-19; and<br><br> 3. agree to hand in study samples (stool and blood); and<br><br> 4. agree to sign the informed consent<br><br>Exclusion Criteria:<br><br> - None
Exclusion Criteria
Not provided
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To identify and compare the microbiome profile and immune response
- Secondary Outcome Measures
Name Time Method SARS-CoV-2 IgG antibody level;Compare the serum neutralization assay against pseudovirus and live virus, as well as the detection of IgM and IgG against receptor-binding domain [RBD] and S1;SARS-CoV-2 specific antibody