Effectiveness of Topical creams in reducing knee pain: a double-blinded randomised study

Not Applicable

Withdrawn

• Conditions: osteoarthritis; Musculoskeletal - Osteoarthritis

• Registration Number: ACTRN12619001299190
• Lead Sponsor: The Joint Studio

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-09-20
• Last Update Posted: 10 February 2020

Recruitment & Eligibility

• Status: Withdrawn
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Inclusion:
1.The individual has signed a Patient Informed Consent (PIC) specific to this study, and approved by the Institutional Ethics Review Board.
2.The individual is between 18 and 80 years of age.
3.The individual clinically presents with Grade 2 or higher osteoarthritis of the knee OR has undergone uncomplicated primary TKR in the previous 2 weeks.

Exclusion Criteria

Exclusion:
1.Persistent opioid medication use > 3 months
2.Is pregnant or planning to become pregnant
3.Surgical invention planned in < 2 months
4.Comorbidities of complex pain disorder or severe mobility compromise (eg. complex regional pain syndrome, severe back pain, gout, multiple sclerosis, muscular mystrophy, Parkinson’s disease, morbidly obese, hemiplegic).
5.Known allergy to egg, or ketoprofen
6.Taking blood thinners eg. warfarin, apixaban, ticagrelor, rivaroxaoba, dabigatran
7.The individual is a prisoner, physically or mentally compromised, is unwilling or unable to comply with scheduled evaluations and/or treatment (eg. Vegan unwilling to use egg-based conduit)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Knee pain <br>VAS Score (with anchors 0-10)[4 weeks following twice daily application]

Secondary Outcome Measures

Name	Time	Method
Sleep disturbance VAS[4 weeks following twice daily application];Forgotten knee joint scale[4 weeks following twice daily application]