Reduction Ratio and Clearance of Middle Molecules During a Single Hemodialysis Session With Medium Cut-Off (MCO) Filter Compared to Hemodiafiltration (HDF) With Standard High-flux Filter
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Chronic Kidney Failure
- Sponsor
- Region Skane
- Enrollment
- 18
- Locations
- 1
- Primary Endpoint
- Reduction ratio (RR) of middle molecules (Beta-2-microglobulin, Cystatin C, Myoglobin, Beta-Trace Protein, Troponin T, Prealbumin)
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
The Medium Cut-Off dialysis (MCO) membrane has been developed to improve middle molecule removal compared to standard high-flux dialysis filters.
The major aim of this study is to compare the reduction ratio of middle molecules, during a single hemodialysis session with MCO-filter, compared to hemodiafiltration (HDF) with standard high-flux filter.
Secondary aims are to compare the reduction ratio of small and large molecules between the treatments.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Ongoing HDF treatment
- •No Acute Myocardial Infarction within 3 months.
Exclusion Criteria
- •Not able to understand the study information.
Outcomes
Primary Outcomes
Reduction ratio (RR) of middle molecules (Beta-2-microglobulin, Cystatin C, Myoglobin, Beta-Trace Protein, Troponin T, Prealbumin)
Time Frame: 4 hours
Reduction ratio during a 4h dialysis session. (Predialysis concentration - Postdialysis concentration)/Predialysis concentration\*100%
Instantaneous arteriovenous clearance of middle molecules (Beta-2-microglobulin, Cystatin C, Myoglobin, Beta-Trace Protein, Troponin T, Prealbumin)
Time Frame: 240 minutes
Instantaneous arteriovenous clearance (ml/min) at 240 minutes of dialysis.
Secondary Outcomes
- Number of Adverse Events(4 hours)
- RR of large molecules (Albumin, Transferrin, IgG)(4 hours)
- RR of small molecules (Urea, Phosphate, Creatinine)(4 hours)
- Instantaneous arteriovenous clearance of large molecules (Albumin, Transferrin, IgG)(240 minutes)
- Instantaneous arteriovenous clearance of small molecules (Urea, Phosphate, Creatinine)(240 minutes)