ew biomarkers of endothelial dysfunctio
Phase 4
Completed
- Conditions
- Essential arterial hypertension, endothelial dysfunctionCirculatory SystemEssential (primary) hypertension
- Registration Number
- ISRCTN92249277
- Lead Sponsor
- Victor Babes University of Medicine and Pharmacy
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 112
Inclusion Criteria
1. Age >18 years
2. Established diagnosis of primary arterial hypertension
Exclusion Criteria
1. Atherosclerotic disease
2. Coronary artery disease
3. Heart failure
4. Diabetes
5. Renal and hepatic pathologies
6. Asthma
7. Acute and chronic inflammatory diseases
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Arterial pressure was measured after 30 minutes of rest, in a supine position, at the right brachial artery<br>2. The presence/absence of endothelial dysfunction was assessed using flow mediated dilation (FMD) and intimal-medial thickness (IMT)<br>3. Plasma levels of TSP-1, PTX3 (pentraxin-3) and hs-CRP (high-selectivity C reactive protein) measured using the ELISA method (TSP-1, PTX3) and the high sensitive immunoturbidimetric method (hs-CRP)<br>All outcomes measured at baseline and after one year of treatment
- Secondary Outcome Measures
Name Time Method 1. Cardiovascular morbidity and mortality were measured using clinical examination of patients, electrocardiography, blood pressure measurements every time the patients visited the doctor<br>2. Incidence of strokes, myocardial infarction, and heart failure were measured using electrocardiography, echocardiography by determining the specific parameters in every visit and also by evaluating the presence of clinical symptoms<br>All outcomes measured at baseline and after one year of treatment