Psychophysiological stress mechanisms in chronic inflammatory diseases; an experimental study

• Conditions: psoriasis; rheumatoid arthritis; 10023213; 10011063

• Registration Number: NL-OMON30321
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 160

Inclusion Criteria

Patients diagnosed with rheumatoid arthritis (Arnett et al., 1988) or psoriasis (van de Kerkhof, 2003). This criterion is not applicable to healthy controls
18 years or older
Informed consent

Exclusion Criteria

Severe physical comorbid conditions (e.g. psoriatic arthritis, malignancy, renal insufficiency)
Psychiatric disturbances that interfere with the study protocol
pregnancy
non-Dutch speakers

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Psychological distress (anxiety and depression)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Fysiologic assessments: concentrations cortisol, ACTH, IL-1, IL-6, IL-18, MIF<br /><br>en TNF-alfa<br /><br><br /><br>Other measurements:<br /><br>- Clinical assessment of disease activity (DAS or PASI)<br /><br>- Autonomous stress response (heart rate variability and skin conductance)<br /><br>- Self-reported variables (using standardized questionnaires) such as<br /><br>self-reported disease activity, physical symptoms (f.e. pain, itching,<br /><br>fatigue), psychological risk factors and stressors</p><br>