Evaluation of Caries Regression, Color Improvement and Mineral Content of White Spot Lesions Post-orthodontic Treatment After Remineralization With Remin Pro Forte Versus Remin Pro: A Randomized Clinical Trial
试验速览
- 阶段
- 不适用
- 入组人数
- 40
- 主要终点
- caries regression
研究概览
简要总结
randomized clinical trial to evaluate caries regression, the change in colour and mineral content of the demineralized enamel after treatment with Remin Pro Forte paste (fluoride, hydroxyapatite, xylitol, ginger, and curcuma) and Remin pro cream which contains (fluoride, hydroxyapatite, xylitol) remineralizing agents with the null hypothesis that Remin Pro forte will have the same clinical performance as Remin Pro in remineralizing white spot lesions post-orthodontic treatment.
详细描述
Recently, a remineralizing water based cream containing Hydroxyapatite, Fluoride and Xylitol (Remin pro) has been introduced. It has been claimed that hydroxyapatite fills eroded enamel, fluoride seals dentinal tubules and xylitol acts as an antibacterial agents. This product has been assumed to be suitable for management of dentinal hypersensitivity, prevention of enamel demineralization and promoting remineralization of enamel subsurface lesions. There are few studies regarding the effect of calcium phosphate and hydroxyapatite-based agents on remineralization and optical appearance of White spot lesions following orthodontic therapy.
Recently a new formulation of Remin pro has been introduced called (Remin Pro Forte) with the same components of fluoride, hydroxyapatite, xylitol in addition to two natural products (Ginger, curcuma) with the rationale based behind that they have antibacterial effect against streptococcus mutans in addition to anti-cariogenic effect which is being confirmed in the scientific literature.
Follow up period is selected to be 3 months, which is enough for evaluation of the outcomes (caries regression, color change, mineral content) assessed in this study.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
盲法说明
Triple (participant,investigator,outcomes assessor)
入排标准
- 年龄范围
- 12 Years 至 25 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •No systemic disease.
- •Has completed fixed orthodontic treatment, brackets debonded.
- •Has at least two teeth with white spot lesion.
- •Has received conventional periodontal therapy after orthodontic treatment.
- •Between the ages of 12 and 25 years of age.
排除标准
- •Presence of enamel hypoplasia or dental fluorosis.
- •Presence of tetracycline pigmentation.
- •Periodontal pocketing of 3mm or greater.
- •Taking antibiotics.
- •Presence of carious cavities.
- •Allergy to fluoride gel / varnish being used in study.
- •Subjects who had evidence of reduced salivary flow or significant tooth wear
结局指标
主要结局
caries regression
时间窗: 3 months
The assessment will be done by photographic image records and performing ICDAS II scoring on white spot lesions on the image records.
次要结局
- color improvement(3 months)
研究者
mennatallah aboulnaga
Assistant lecturer
Cairo University