A Prospective Randomised Controlled Trial to Study the Effects of Recombinant Human Erythropoietin on the Progression of Atherosclerosis, Cardiovascular Function, Nutrition and Residual Renal Function in Pre-dialysis Chronic Renal Failure Patients

Hospital Authority, Hong Kong1 site in 1 country66 target enrollmentFebruary 2001

ConditionsChronic Disease Kidney Diseases Cardiovascular Diseases

Drugserythropoietin

Overview

Phase: N/A
Intervention: Not specified
Conditions: Chronic Disease
Sponsor: Hospital Authority, Hong Kong
Enrollment: 66
Locations: 1
Primary Endpoint: endothelial function and atherosclerosis
Status: Completed
Last Updated: 14 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The primary aim of the study is to evaluate the effects of correction of anemia using erythropoietin on the progression of atherosclerosis and cardiac muscle thickening in patients with chronic kidney disease

Registry

clinicaltrials.gov

Start Date

February 2001

End Date

November 2003

Last Updated

14 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Hospital Authority, Hong Kong

Eligibility Criteria

Inclusion Criteria

•Patients with chronic renal failure with serum creatinine between 150umol/L and 800umol/L and at the same time Hb
•Patients with regression line of 1/serum creatinine versus time showing that they may not require dialysis within the coming 12 months
•Patients below the age of 75

Exclusion Criteria

•Patients with valvular heart disease/congenital heart disease
•Patients with ischemic heart disease/history of myocardial infarction/coronary artery bypass surgery
•Patients with history of heart failure
•Patients with regression line of 1/serum creatinine versus time showing that the estimated date of end stage renal disease is within 12 months
•Patients with thalassemic trait or haemoglobinopathies
•Patients with underlying haematological malignancies
•Patients with active bleeding
•Patients with uncorrected iron or other vitamins deficiencies
•Patients with poor general condition