Comparion of the infusion rate of rocuronium necessary for obtain adequate surgical muscle relaxation between before and during hepatectomy with Pringle maneuver.

Not Applicable

• Conditions: Surgical patients requiring hepatectomy with Pringle maneuver

• Registration Number: JPRN-UMIN000023479
• Lead Sponsor: Saitama Medical Center, Jichi Medical University

Brief Summary

The infusion rate of rocuronium before, during, and after the Pringle maneuver was 7.2 plus or minus 1.8, 4.2 plus or minus 1.4, and 4.7 plus or minus 1.5 mcg/kg/min (mean plus or minus SD), respectively. The rocuronium infusion rate during the Pringle maneuver was decreased about 40% compared to that before this maneuver, and that after completion of the Pringle maneuver was not recovered to that before the Pringle maneuver. The 25% recovery time was 20 plus or minus 7 min.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-08-08
• Study Completion: 2017-06-30
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 18

Inclusion Criteria

Not provided

Exclusion Criteria

excluded if any one of the following criteria applied: 1) probably pregnant 2) abnormal serum electrolytes (Na +, K +, or Cl-) 3) renal dysfunction (serum creatinine greater than 2.0 mg/dl) 4) liver dysfunction (ALT and/or AST beyond twice the normal range) 5) ICG15=>15% 6) Child-Pugh classification=>B 7) emaciation (body mass index (BMI) less than 17), obesity (BMI more than 30) 8) neuromuscular disorders, 9) a history of hypersensitive reaction to Rb, 10) a history of treatment with drugs known to interact with Rb, such as aminoglycoside antibiotics, anticonvulsants, formulation lithium, or magnesium 11) hypothermia during anesthesia 12) systemic allergy 13) inappropriate patients judged by physician-in-charge

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
continuous infusion rate for obtain muscle relaxasion(before, during, and after Pringle maneuver)

Secondary Outcome Measures

Name	Time	Method
measured blood concentration of rocuronium during stable state of optimalmuscle relaxation