Lactate Dehydrogenase, Bowel Necrosis and Mortality in Acute Mesenteric Ischemia: Retrospective Cross-Sectional
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 74
- 试验地点
- 1
- 主要终点
- Bowel necrosis length in cm
研究概览
简要总结
Background: Acute mesenteric ischemia is a vascular emergency with high mortality because of ambiguous symptomatology and a lack of early diagnostic markers. Lactate dehydrogenase has been described as a mortality biomarker and bowel necrosis length too. Nevertheless, the association between them has been mildly studied. Our objective was to evaluate the association between serum lactate admission levels, bowel necrosis extension, and mortality. Additionally, we performed a mortality characterization.
Materials and Methods: A retrospective cross-sectional study was designed. We reviewed patients' clinical records with acute mesenteric ischemia that attended a hospital between 2012 and 2018. We compared serum lactate admission levels with bowel necrosis length and mortality. A receiver operating characteristic curve was performed on the last association. As post hoc analysis, a classification and regression tree on mortality was fitted.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Older than 18 years of age
- •Required urgent laparotomy with a postoperative diagnosis of acute mesenteric ischemia
- •Attended the private academic hospital, between 2012 and 2018
- •Had a registered serum lactate dehydrogenase at admission
排除标准
- •Secondary causes of AMI
- •Chronic intestinal ischemic
- •Patient records with no description of the serum lactate dehydrogenase or extension of intestinal necrosis
结局指标
主要结局
Bowel necrosis length in cm
时间窗: 30 days
Serum Lactate in mmol/l
时间窗: 30 days
Percentage of patients that died between 30 postsurgical days, %
时间窗: 30 days
次要结局
- Cut value of lactate levels as a predictor of mortality, in mmol/l(30 days)
研究者
Andrés Isaza Restrepo
MD, MSc
Universidad del Rosario