NCT02894047已完成不适用
Study of the Influence of the Expression of the Calcium-sensitive Receptor (CaSR) by Monocytes in the Synovial Liquid on Structural Alterations in Patients Diagnosed With Rheumatoid Arthritis in the Previous Two Years
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 42
- 试验地点
- 1
- 主要终点
- CaSR expression rate level on synovial monocytes
研究概览
简要总结
Rheumatoid arthritis (RA) is the most frequent form of chronic inflammatory rheumatism in adults. The erosive damage influences the functional prognosis in patients with RA. At present, there are no sufficiently sensitive and specific predictive markers of erosive damage.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients consulting in the Department of Rheumatology at Amiens University Hospital
- •RA meeting the 2010 ACR/EULAR criteria
- •Less than 2 years of RA progression
- •Effusion in at least 1 joint
排除标准
- •Inability to give informed consent
- •Ongoing pregnancy
- •Previous treatment with an anti-osteoporosis medication
- •Intra-articular corticoid or hyaluronic acid injection in the previous 6 months
- •Coagulation disorders preventing arthrocentesis
- •Incarceration or legal guardianship
结局指标
主要结局
CaSR expression rate level on synovial monocytes
时间窗: 1 year
measured by flow cytometry
次要结局
未报告次要终点
研究者
研究点 (1)
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