Study of the Influence of the Expression of the Calcium-sensitive Receptor (CaSR) by Monocytes in the Synovial Liquid on Structural Alterations in Patients Diagnosed With Rheumatoid Arthritis in the Previous Two Years
Completed
- Conditions
- Arthritis, Rheumatoid
- Registration Number
- NCT02894047
- Lead Sponsor
- Centre Hospitalier Universitaire, Amiens
- Brief Summary
Rheumatoid arthritis (RA) is the most frequent form of chronic inflammatory rheumatism in adults. The erosive damage influences the functional prognosis in patients with RA. At present, there are no sufficiently sensitive and specific predictive markers of erosive damage.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 42
Inclusion Criteria
- Patients consulting in the Department of Rheumatology at Amiens University Hospital
- Age ≥ 18
- RA meeting the 2010 ACR/EULAR criteria
- Less than 2 years of RA progression
- Effusion in at least 1 joint
Exclusion Criteria
- Inability to give informed consent
- Ongoing pregnancy
- Previous treatment with an anti-osteoporosis medication
- Intra-articular corticoid or hyaluronic acid injection in the previous 6 months
- Coagulation disorders preventing arthrocentesis
- Incarceration or legal guardianship
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method CaSR expression rate level on synovial monocytes 1 year measured by flow cytometry
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
CHU Amiens
🇫🇷Amiens, France